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MAP3K1 - Map3k1 mitogen-activated protein kinase kinase kinase 1 Gene

Also Known as Mekk1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 116667

Summary

Enables several functions, including JUN kinase kinase kinase activity; protein kinase binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; positive regulation of MAPK cascade; and positive regulation of viral transcription. Located in cytoplasm and membrane. Colocalizes with Cytoskeleton. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast Cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

MAP3K1 Products (1)

mRNA	Protein	Name
NM_053887.2	NP_446339.2	mitogen-activated protein kinase kinase kinase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables JUN kinase binding	IPI IPI: Inferred from physical interaction	16006144	RGD
enables JUN kinase kinase kinase activity	IDA IDA: Inferred from direct assay	9110999	RGD
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	7624324	RGD
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	12049732	RGD
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	7624324	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	25260751	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11784851	RGD
enables sphingolipid binding	IPI IPI: Inferred from physical interaction	15164763	RGD
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	12049732	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	9110999	RGD
involved in negative regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	9155015	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	7624324	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20128690	RGD
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	9110999	RGD
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	9110999	RGD
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	9110999	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	7624324	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17101801	RGD
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20128690	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9155015	RGD
involved in positive regulation of viral transcription	IDA IDA: Inferred from direct assay	11746500	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12049732	RGD
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	11784851	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9110999	RGD
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	12049732	RGD
involved in ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	12049732	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 1	MAPK/ERK kinase kinase 1 MEK kinase 1 MEKK 1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

MAP3K1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Map3k1	Q62925	UBE2N	Homo sapiens	P61088	Ubiquitinase Assay	25260751
Cross	Map3k1	Q62925	TRAF2	Homo sapiens	Q12933	Ubiquitinase Assay	25260751
Cross	Map3k1	Q62925	TRAF2	Homo sapiens	Q12933	Y2H	25260751

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-208723	MAP3K1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MAP3K1	NCBI	NCBI:4214