F2rl1 - F2R like trypsin receptor 1 Gene

Also Known as Par2; Par-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116677

About F2rl1

Primary_assembly 2: 26,772,278-26,785,226 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 307 orthologues, 14 paralogues and is associated with 12 phenotypes. Biased expression in Kidney (RPKM 28.2), Heart (RPKM 22.9) and 8 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in positive regulation of glomerular filtration. Acts upstream of or within with a positive effect on vasodilation. Predicted to be located in early endosome; plasma membrane; and pseudopodium. Predicted to be integral component of plasma membrane. Biomarker of lung disease. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

F2rl1 Products (1)

mRNA Protein Name
NM_053897.3 NP_446349.1 proteinase-activated receptor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17693410 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of glomerular filtration IDA
IDA: Inferred from direct assay
12644441 RGD
acts upstream of or within positive effect vasodilation IDA
IDA: Inferred from direct assay
11884377 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
12644441 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2rl1 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (75 - 354)

7tm_GPCRs

7tm_GPCRs: cd14964 (77 - 101)

7tm_GPCRs

7tm_GPCRs: cd14964 (110 - 131)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 170)

7tm_GPCRs

7tm_GPCRs: cd14964 (192 - 208)

7tm_GPCRs

7tm_GPCRs: cd14964 (239 - 262)

7tm_GPCRs

7tm_GPCRs: cd14964 (285 - 307)

7tm_GPCRs

7tm_GPCRs: cd14964 (322 - 347)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

proteinase-activated receptor 2

  • Proteinase-activated receptor-2, G protein-coupled receptor 11

  • coagulation factor II (thrombin) receptor-like 1

  • coagulation factor II receptor-like 1

  • thrombin receptor-like 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04634 F2RL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04635 F2rl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04636 F2rl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F2rl1 NCBI NCBI:2150