LEAP2 - liver enriched antimicrobial peptide 2 Gene

Also Known as LEAP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116842

About LEAP2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:132,873,668-132,875,046 (from NCBI)

This gene has 3 transcripts (splice variants) and 116 orthologues. Biased expression in liver (RPKM 158.3), small intestine (RPKM 13.5) and 1 other tissue.

Summary

This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]

LEAP2 Products (1)

mRNA Protein Name
NM_052971.3 NP_443203.1 liver-expressed antimicrobial peptide 2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
12493837 GOA
involved in defense response to fungus IMP
IMP: Inferred from mutant phenotype
12493837 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LEAP2 Protein Structure

LEAP-2

LEAP-2: Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) (1 - 77)

  • 0
  • 77 a.a.
Protein Preferred Names Protein Names

liver-expressed antimicrobial peptide 2

Related Diseases

Diseases Alias
Listeria Meningitis

  • Meningitis, Listeria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5645 LEAP-2 97.75% Unkown
HY-RS07582 LEAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LEAP2 RGD RGD:1561235
Mus musculus LEAP2 MGD MGI:2672795
Canis familiaris LEAP2 VGNC VGNC:42628
Felis catus LEAP2 VGNC VGNC:102242
Bos taurus LEAP2 VGNC VGNC:30831
Macaca mulatta LEAP2 VGNC VGNC:74161
Others LEAP2 NCBI