Cflar - CASP8 and FADD-like apoptosis regulator Gene

Also Known as Flip

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117279

Summary

Enables death receptor binding activity and protease binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in membrane raft. Part of CD95 death-inducing signaling complex. Orthologous to human CFLAR (CASP8 and FADD like Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Cflar Products (2)

mRNA Protein Name
NM_001033864.4 NP_001029036.1 CASP8 and FADD-like apoptosis regulator isoform 1
NM_057138.3 NP_476479.1 CASP8 and FADD-like apoptosis regulator isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables death receptor binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
17518537 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17518537 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
16167066 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
16033771 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
26566102 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
12031707 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
18292530 RGD
involved in cellular response to nitric oxide IMP
IMP: Inferred from mutant phenotype
18292530 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12135878 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
14596792 RGD
involved in negative regulation of cellular response to transforming growth factor beta stimulus IMP
IMP: Inferred from mutant phenotype
18314484 RGD
involved in negative regulation of epithelial cell apoptotic process IDA
IDA: Inferred from direct assay
18314484 RGD
involved in negative regulation of hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16167066 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
18292530 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23412386 RGD
involved in positive regulation of extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
24691542 RGD
involved in positive regulation of glomerular mesangial cell proliferation IMP
IMP: Inferred from mutant phenotype
24691542 RGD
involved in positive regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
16033771 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
20427667 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
23926673 RGD
involved in response to testosterone IDA
IDA: Inferred from direct assay
12811833 RGD
Cellular Component GO Annotation Evidence References Source
part of CD95 death-inducing signaling complex IDA
IDA: Inferred from direct assay
16493077 RGD
part of death-inducing signaling complex IDA
IDA: Inferred from direct assay
17518537 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CASP8 and FADD-like apoptosis regulator

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02570 CFLAR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21525 Cflar Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28043 Cflar Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cflar NCBI NCBI:8837