Park7 - Parkinsonism associated deglycase Gene

Also Known as Dj1; CAP1; DJ-1; SP22

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117287

Summary

Predicted to enable several functions, including enzyme activator activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of NMDA glutamate receptor activity; and positive regulation of fertilization. Located in several cellular components, including membrane raft; mitochondrion; and sperm head. Used to study Parkinson's disease and Parkinsonism. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Apr 2022]

Park7 Products (12)

mRNA Protein Name
NM_001277249.1 NP_001264178.1 Parkinson disease protein 7 homolog isoform 1
NM_001277250.1 NP_001264179.1 Parkinson disease protein 7 homolog isoform 2
NM_001277251.1 NP_001264180.1 Parkinson disease protein 7 homolog isoform 2
NM_001277252.1 NP_001264181.1 Parkinson disease protein 7 homolog isoform 2
NM_001277253.1 NP_001264182.1 Parkinson disease protein 7 homolog isoform 2
NM_057143.2 NP_476484.1 Parkinson disease protein 7 homolog isoform 2
NM_001277249.1 NP_001264178.1 Parkinson disease protein 7 homolog isoform 1
NM_001277250.1 NP_001264179.1 Parkinson disease protein 7 homolog isoform 2
NM_001277251.1 NP_001264180.1 Parkinson disease protein 7 homolog isoform 2
NM_001277252.1 NP_001264181.1 Parkinson disease protein 7 homolog isoform 2
NM_001277253.1 NP_001264182.1 Parkinson disease protein 7 homolog isoform 2
NM_057143.2 NP_476484.1 Parkinson disease protein 7 homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16854843 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
29069575 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23847046 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
17609507 RGD
involved in negative regulation of NMDA glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
20698836 RGD
involved in negative regulation of smooth muscle cell migration IDA
IDA: Inferred from direct assay
29069575 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
29069575 RGD
involved in positive regulation of fertilization IMP
IMP: Inferred from mutant phenotype
11780923 RGD
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16227205 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17038803 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
11780923 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15673657 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
31536960 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
31536960 RGD
located in sperm head IDA
IDA: Inferred from direct assay
11780923 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Parkinson disease protein 7 homolog

  • Parkinson disease (autosomal recessive, early onset) 7

  • contraception-associated protein 1

  • fertility protein SP22

  • maillard deglycase

  • parkinson disease protein 7 homolog

  • parkinson protein 7

  • protein DJ-1

  • protein deglycase DJ-1

  • protein/nucleic acid de

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163562 JYQ-164 Inhibitor 99.43% Unkown
HY-163563 JYQ-173 Inhibitor 99.78% Unkown
HY-163564 JYQ-194 Degrader 98.05% Unkown
HY-RS10043 PARK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17611 Park7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24071 Park7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Park7 NCBI NCBI:11315