Kif1b - kinesin family member 1B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117548

Summary

Enables several functions, including ATP hydrolysis activity; microtubule motor activity; and scaffold protein binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; dense core granule cytoskeletal transport; and response to rotenone. Located in several cellular components, including cytoplasmic vesicle; mitochondrion; and neuron projection. Biomarker of amyotrophic lateral sclerosis and synucleinopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Orthologous to human KIF1B (Kinesin family member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Kif1b Products (1)

mRNA Protein Name
NM_057200.2 NP_476548.1 kinesin-like protein KIF1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
19744141 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
12097473 RGD
enables microtubule motor activity IDA
IDA: Inferred from direct assay
19744141 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12204119 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12097473 RGD
Biological Process GO Annotation Evidence References Source
involved in anterograde neuronal dense core vesicle transport IGI
IGI: Inferred from genetic interaction
28426968 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
24469107 RGD
involved in lysosome localization IMP
IMP: Inferred from mutant phenotype
15086790 RGD
involved in organelle transport along microtubule IMP
IMP: Inferred from mutant phenotype
15086790 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24469107 RGD
involved in protein localization to cell periphery IMP
IMP: Inferred from mutant phenotype
15086790 RGD
involved in response to rotenone IEP
IEP: Inferred from expression pattern
23263842 RGD
involved in retrograde neuronal dense core vesicle transport IGI
IGI: Inferred from genetic interaction
28426968 RGD
involved in transport along microtubule IDA
IDA: Inferred from direct assay
19744141 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12204119 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
17571083 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
12204119 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin-like protein KIF1B

  • kinesin-family protein KIF1Bbeta3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07270 KIF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21616 Kif1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28134 Kif1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif1b NCBI NCBI:23095