Araf - Araf proto-oncogene, serine/threonine kinase Gene

Also Known as A-Raf; Araf1; 1200013E08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11836

Summary

Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in several processes, including MAPK cascade; regulation of TOR signaling; and regulation of cellular protein metabolic process. Predicted to act upstream of or within phosphorylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and retina. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Araf Products (2)

mRNA Protein Name
NM_001159645.1 NP_001153117.1 serine/threonine-protein kinase A-Raf isoform 2
NM_009703.2 NP_033833.1 serine/threonine-protein kinase A-Raf isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
9488663 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in mitochondrion IDA
IDA: Inferred from direct assay
12931191 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase A-Raf

  • A-Raf proto-oncogene serine/threonine-protein kinase

  • proto-oncogene A-Raf

  • raf-related oncogene

  • v-raf murine sarcoma 3611 viral oncogene homolog 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-158115 NST-628 Inhibitor 99.35% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-162752 Anticancer agent 250 / Unkown
HY-169869 pan-Raf/RTK inhibitor 1 Inhibitor / Unkown
HY-178042 SS-3091 Inhibitor / Unkown
HY-18652A Avutometinib potassium Inhibitor / Unkown
HY-E70103I exo-α-1,3-Arabinofuranosidase, Penicillium chrysogenum / Unkown
HY-RS00886 ARAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18462 Araf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24943 Araf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Araf NCBI NCBI:369