Arf6 - ADP-ribosylation factor 6 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11845

Summary

Enables protein N-terminus binding activity. Involved in several processes, including negative regulation of protein localization to cell surface; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Acts upstream of or within several processes, including hepatocyte apoptotic process; liver development; and myeloid cell apoptotic process. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Arf6 Products (1)

mRNA Protein Name
NM_007481.3 NP_031507.1 ADP-ribosylation factor 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20493856 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within erythrocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16880525 MGI
acts upstream of or within establishment of epithelial cell polarity IMP
IMP: Inferred from mutant phenotype
20080746 MGI
acts upstream of or within hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16880525 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
16880525 MGI
involved in negative regulation of protein localization to cell surface IDA
IDA: Inferred from direct assay
29420262 MGI
involved in positive regulation of focal adhesion disassembly IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
16751103 MGI
involved in protein localization to cell surface IDA
IDA: Inferred from direct assay
16751103 MGI
involved in protein localization to endosome IMP
IMP: Inferred from mutant phenotype
23572513 MGI
involved in regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
16325184 MGI
acts upstream of or within regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
27330119 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8947846 MGI
located in endosome IDA
IDA: Inferred from direct assay
16751103 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8947846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP-ribosylation factor 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112473 Grassofermata Inhibitor 99.10% Unkown
HY-139950 Rasarfin Inhibitor 99.57% Unkown
HY-RS00898 ARF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10178 Myristoylated ARF6 (2-13) Inhibitor / Unkown
HY-P10179 ARF6 (2-13) / Unkown
HY-RS18229 Arf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24708 Arf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arf6 NCBI NCBI:382