Atp1b2 - ATPase, Na+/K+ transporting, beta 2 polypeptide Gene

Also Known as Amog; Atpb-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11932

Summary

Predicted to enable several functions, including ATPase binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in cell-substrate adhesion; negative regulation of glial cell migration; and positive regulation of neuron projection development. Acts upstream of or within several processes, including brain development; motor behavior; and photoreceptor cell maintenance. Located in several cellular components, including astrocyte end-foot; cell body membrane; and photoreceptor inner segment. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and retina. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp1b2 Products (1)

mRNA	Protein	Name
NM_013415.6	NP_038201.1	sodium/potassium-transporting ATPase subunit beta-2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cell-substrate adhesion	IDA IDA: Inferred from direct assay	12887597	MGI
acts upstream of or within lateral ventricle development	IMP IMP: Inferred from mutant phenotype	7525597	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	7525597	MGI
involved in negative regulation of glial cell migration	IDA IDA: Inferred from direct assay	12887597	MGI
acts upstream of or within neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration	IMP IMP: Inferred from mutant phenotype	2438288	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	7525597	MGI
acts upstream of or within plasma membrane bounded cell projection organization	IMP IMP: Inferred from mutant phenotype	7525597	MGI
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	7504672	MGI
acts upstream of or within retina homeostasis	IMP IMP: Inferred from mutant phenotype	8793730	MGI
acts upstream of or within third ventricle development	IMP IMP: Inferred from mutant phenotype	7525597	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21705333	MGI
located in astrocyte end-foot	IDA IDA: Inferred from direct assay	2438288	MGI
located in astrocyte projection	IDA IDA: Inferred from direct assay	2438288	MGI
located in cell body membrane	IDA IDA: Inferred from direct assay	28373281	MGI
located in cell projection membrane	IDA IDA: Inferred from direct assay	28373281	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10859164	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	2438288	MGI
located in neuron to neuron synapse	IDA IDA: Inferred from direct assay	21196491	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	21196491	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	28373281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sodium/potassium-transporting ATPase subunit beta-2	adhesion molecule in glia glial cell adhesion molecule sodium/potassium-dependent ATPase subunit beta-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01187	ATP1B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21823	Atp1b2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp1b2	NCBI	NCBI:482