Axin2 - axin 2 Gene

Also Known as Axi1; Axil; Conductin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12006

Summary

Enables I-SMAD binding activity and ubiquitin protein Ligase binding activity. Involved in regulation of centromeric sister chromatid cohesion. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and regulation of chondrocyte development. Located in centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in colorectal Cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Apr 2022]

Axin2 Products (1)

mRNA Protein Name
NM_015732.4 NP_056547.3 axin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables I-SMAD binding IPI
IPI: Inferred from physical interaction
16601693 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9554852 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16601693 MGI
Biological Process GO Annotation Evidence References Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
28069701 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
19623616 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15790973 MGI
acts upstream of or within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
19623616 MGI
acts upstream of or within intramembranous ossification IMP
IMP: Inferred from mutant phenotype
15790973 MGI
involved in mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
28069701 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
28069701 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15790973 MGI
acts upstream of or within negative regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
15790973 MGI
acts upstream of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15790973 MGI
acts upstream of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
15790973 MGI
acts upstream of or within regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
9554852 MGI
involved in regulation of centromeric sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
20300119 MGI
acts upstream of or within regulation of chondrocyte development IMP
IMP: Inferred from mutant phenotype
19623616 MGI
involved in regulation of extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
28069701 MGI
acts upstream of or within secondary heart field specification IGI
IGI: Inferred from genetic interaction
22711842 MGI
acts upstream of or within somitogenesis IDA
IDA: Inferred from direct assay
12636920 MGI
acts upstream of or within stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20569694 MGI
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
20300119 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21991325 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

axin-2

  • axin-like protein

  • axis inhibition protein 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-137849 RK-582 Inhibitor 98.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-112799 DK419 Inhibitor 99.86% Unkown
HY-163767 Antitumor agent-171 Inhibitor 98.48% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-165503 AZ1366 Inhibitor / Unkown
HY-180449 AXIN2/β-catenin-IN-1 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-RS01292 AXIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20863 Axin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27378 Axin2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991311 GSK3178022 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Axin2 NCBI NCBI:8313