SLC36A4 - solute carrier family 36 member 4 Gene

Also Known as PAT4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 120103

About SLC36A4

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:93,144,174-93,197,991 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 15 paralogues. Ubiquitous expression in brain (RPKM 3.7), bone marrow (RPKM 3.3) and 25 other tissues.

Summary

SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with Other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 Amino acids and have 9 to 11 transmembrane domains. Unlike Other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled Amino acid Transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]

SLC36A4 Products (2)

mRNA	Protein	Name
NM_001286139.2	NP_001273068.1	proton-coupled amino acid transporter 4 isoform 2
NM_152313.4	NP_689526.2	proton-coupled amino acid transporter 4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables L-alanine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21097500	GOA
enables L-proline transmembrane transporter activity	EXP EXP: Inferred from Experiment	21097500	GOA
enables L-proline transmembrane transporter activity	IDA IDA: Inferred from direct assay	21097500	GOA
enables L-tryptophan transmembrane transporter activity	EXP EXP: Inferred from Experiment	21097500	GOA
enables L-tryptophan transmembrane transporter activity	IDA IDA: Inferred from direct assay	21097500	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-alanine transport	IDA IDA: Inferred from direct assay	21097500	GOA
involved in proline transport	IDA IDA: Inferred from direct assay	21097500	GOA
involved in tryptophan transport	IDA IDA: Inferred from direct assay	21097500	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC36A4 Protein Structure

Aa_trans

0
100
200
300
400
504 a.a.

Protein Preferred Names	Protein Names
proton-coupled amino acid transporter 4	solute carrier family 36 (proton/amino acid symporter), member 4

Related Diseases

Diseases	Alias
Iminoglycinuria	Iminoglycinuria, Digenic IG
Epilepsy, Juvenile Absence 1	Epilepsy, Juvenile Absence, Susceptibility To, 1 EJA1 JAE1 Juvenile Absence Epilepsy 1 Susceptibility To Juvenile Absence Epilepsy 1 Epilepsy, Juvenile Absence, Susceptibility To, Type 1 Absence Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13212	SLC36A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC36A4	VGNC	VGNC:46385
Rattus norvegicus	SLC36A4	RGD	RGD:1311528
Bos taurus	SLC36A4	VGNC	VGNC:34841
Macaca mulatta	SLC36A4	VGNC	VGNC:101398
Mus musculus	SLC36A4	MGD	MGI:2442595
Felis catus	SLC36A4	VGNC	VGNC:65340
Others	SLC36A4	NCBI