Pdia4 - protein disulfide isomerase associated 4 Gene

Also Known as Cai; Erp72; ERp-72

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12304

Summary

Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in chaperone-mediated protein folding; positive regulation of protein folding; and response to endoplasmic reticulum stress. Located in cell surface and endoplasmic reticulum. Part of endoplasmic reticulum chaperone complex. Is expressed in embryo; medulla oblongata basal plate; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Apr 2022]

Pdia4 Products (2)

mRNA Protein Name
NM_001368756.1 NP_001355685.1 protein disulfide-isomerase A4 isoform 1 precursor
NM_009787.2 NP_033917.2 protein disulfide-isomerase A4 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
28576878 MGI
enables protein disulfide isomerase activity IDA
IDA: Inferred from direct assay
28576878 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood coagulation, fibrin clot formation IMP
IMP: Inferred from mutant phenotype
28576878 MGI
acts upstream of or within platelet aggregation IMP
IMP: Inferred from mutant phenotype
28576878 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19995400 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9493907 MGI
part of endoplasmic reticulum chaperone complex IDA
IDA: Inferred from direct assay
12475965 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein disulfide-isomerase A4

  • ER protein 72

  • calcium binding protein, intestinal

  • endoplasmic reticulum protein 72

  • endoplasmic reticulum resident protein 72

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122895 E64FC26 98.48% Unkown
HY-122895A (E/Z)-E64FC26 99.80% Unkown
HY-RS10269 PDIA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17554 Pdia4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24012 Pdia4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdia4 NCBI NCBI:9601