Calcr - calcitonin receptor Gene

Also Known as Clr; Ct-r

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12311

About Calcr

Chromosome 6: 3,685,680-3,764,714 reverse strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 218 orthologues, 41 paralogues and is associated with 9 phenotypes. Biased expression in whole brain E14.5 (RPKM 1.5), CNS E18 (RPKM 1.2) and 5 other tissues.

Summary

Enables Calcitonin receptor activity. Acts upstream of or within several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of ossification; and osteoclast differentiation. Located in acrosomal vesicle and cilium. Is expressed in several structures, including brain; gonad; limb long bone; mammary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (Calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Calcr Products (5)

mRNA Protein Name
NM_001042725.1 NP_001036190.1 calcitonin receptor isoform 1a precursor
NM_007588.2 NP_031614.2 calcitonin receptor isoform 1b precursor
NM_001355192.1 NP_001342121.1 calcitonin receptor isoform 1a precursor
NM_001377018.1 NP_001363947.1 calcitonin receptor isoform 1b precursor
NM_001042725.1 NP_001036190.1 calcitonin receptor isoform 1a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcitonin receptor activity IDA
IDA: Inferred from direct assay
7988453 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
7988453 MGI
acts upstream of or within negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
14970190 MGI
acts upstream of ossification IMP
IMP: Inferred from mutant phenotype
14970190 MGI
acts upstream of or within osteoclast differentiation IDA
IDA: Inferred from direct assay
7664679 MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
9753683 MGI
NOT acts upstream of or within regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
14970190 MGI
acts upstream of or within regulation of mRNA stability IDA
IDA: Inferred from direct assay
9002981 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
12704735 MGI
located in cilium IDA
IDA: Inferred from direct assay
12704735 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Calcr Protein Structure

HRM

HRM: pfam02793 (85 - 153)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (161 - 471)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (163 - 188)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (197 - 219)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (273 - 300)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (312 - 332)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (347 - 376)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (390 - 417)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (423 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
Protein Preferred Names Protein Names

calcitonin receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184982 Estrogen receptor-IN-2 / Unkown
HY-P11584 KBP-066A Agonist / Unkown
HY-RS01832 CALCR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01833 Calcr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01834 Calcr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calcr NCBI NCBI:799