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CALCR - calcitonin receptor Gene

Also Known as CRT; CTR; CT-R; CTR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 799

About CALCR

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,424,486-93,574,724 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues, 42 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a high affinity receptor for the peptide hormone Calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

CALCR Products (3)

mRNA	Protein	Name
NM_001164737.3	NP_001158209.2	calcitonin receptor isoform 1 precursor
NM_001164738.2	NP_001158210.1	calcitonin receptor isoform 2 precursor
NM_001742.4	NP_001733.1	calcitonin receptor isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables amylin receptor activity	IGI IGI: Inferred from genetic interaction	22500019	GOA
enables amylin receptor activity	IPI IPI: Inferred from physical interaction	14722252	GOA
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	22500019	GOA
NOT enables calcitonin binding	IDA IDA: Inferred from direct assay	15563840	GOA
enables calcitonin binding	IDA IDA: Inferred from direct assay	7769107	GOA
enables calcitonin binding	IPI IPI: Inferred from physical interaction	7588285	GOA
enables calcitonin gene-related peptide receptor activity	IPI IPI: Inferred from physical interaction	14722252	GOA
enables calcitonin receptor activity	IDA IDA: Inferred from direct assay	7588285	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7588285	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	7619207	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in amylin receptor signaling pathway	IDA IDA: Inferred from direct assay	14722252	GOA
involved in amylin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in calcitonin gene-related peptide receptor signaling pathway	IDA IDA: Inferred from direct assay	7588285	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of cAMP/PKA signal transduction	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	8078488	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in response to amyloid-beta	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in response to glucocorticoid	IDA IDA: Inferred from direct assay	11250927	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of amylin receptor complex 1	IDA IDA: Inferred from direct assay	22500019	GOA
part of amylin receptor complex 2	IDA IDA: Inferred from direct assay	22500019	GOA
part of amylin receptor complex 3	IDA IDA: Inferred from direct assay	22500019	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCR Protein Structure

HRM

7tm_2

0
100
200
300
400
508 a.a.

Protein Preferred Names	Protein Names
calcitonin receptor

Recombinant CALCR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74359	Calcitonin R Protein, Human (HEK293, hFc)	P30988 (A25-V154)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Holoprosencephaly 6	HPE6
Bone Mineral Density Quantitative Trait Locus 15	Osteoporosis BMND15 Osteoporosis, Susceptibility To Metaphyseal Fracture Metaphyseal Fracture, Susceptibility To Compression Fracture Compression Fracture, Susceptibility To Metaphyseal Fractures Fractures, Compression
Root Resorption
Urolithiasis
Psoriasis 11	PSORS11 Psoriasis 11, Susceptibility To Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Pv
Giant Cell Reparative Granuloma	Central Giant Cell Granuloma Central Giant Cell Reparative Granuloma Of Jaw Central Giant Cell Granuloma Granuloma, Giant Cell Granuloma, Giant Cell Reparative Giant Cell Lesion Of Small Bones Giant Cell Granuloma, Nos
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Bone Giant Cell Tumor	Giant Cell Tumor Of Bone Osteoclastoma Gct Of Bone Bone Giant Cell Tumour Giant Cell Myeloma Giant Cell Neoplasm Of Bone Giant Cell Tumour Of Bone
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Colon Leiomyoma	Colonic Leiomyoma
Mixed Cerebral Palsy	Cerebral Palsy, Mixed
Moyamoya Disease 1	Moyamoya Disease Spontaneous Occlusion Of The Circle Of Willis Mymy Progressive Intracranial Arterial Occlusion Moyamoya Syndrome MYMY1 Cerebrovascular Moyamoya Disease Moya-Moya Disease Progressive Intracranial Occlusive Arteropathy Idiopathic Moyamoya Disease
Osteopetrosis	Albers-Schonberg Disease Marble Bone Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-184982	Estrogen receptor-IN-2		/	Unkown
HY-P11584	KBP-066A	Agonist	/	Unkown
HY-RS01832	CALCR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01833	Calcr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01834	Calcr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CALCR	MGD	MGI:101950
Macaca mulatta	CALCR	VGNC	VGNC:70516
Felis catus	CALCR	VGNC	VGNC:60321
Canis familiaris	CALCR	VGNC	VGNC:38664
Rattus norvegicus	CALCR	RGD	RGD:621001
Bos taurus	CALCR	VGNC	VGNC:26704
Others	CALCR	NCBI