Cbx2 - chromobox 2 Gene

Also Known as pc; M33; MOD2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12416

Summary

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015]

Cbx2 Products (1)

mRNA Protein Name
NM_007623.3 NP_031649.2 chromobox protein homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16687444 MGI
enables methylated histone binding IDA
IDA: Inferred from direct assay
16537902 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9367786 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9312051 MGI
Cellular Component GO Annotation Evidence References Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
9312051 MGI
located in euchromatin IDA
IDA: Inferred from direct assay
18311137 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
16537902 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16537902 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromobox protein homolog 2

  • M33 polycomb-like protein

  • chromobox homolog 2

  • modifier 3 protein

  • polycomb

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147058 SW2_152F Inhibitor 99.51% Unkown
HY-181089 CBX2-IN-1 Inhibitor / Unkown
HY-RS02009 CBX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18605 Cbx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25090 Cbx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbx2 NCBI NCBI:84733