1. Epigenetics
  2. Histone Methyltransferase
  3. SW2_152F

SW2_152F 

Cat. No.: HY-147058
Handling Instructions

SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a Kd of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro.

For research use only. We do not sell to patients.

SW2_152F Chemical Structure

SW2_152F Chemical Structure

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Description

SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a Kd of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro[1].

IC50 & Target

Kd: 80 nM (chromobox 2 chromodomain)[1]

In Vitro

SW2_152F inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

921.35

Formula

C44H60Cl3N7O8

SMILES

ClC1=CC(Cl)=CC(C(N[[email protected]@H](CC2=CC(Cl)=C(O)C=C2)C(N[[email protected]@H](C3CCCC3)C(N[[email protected]@H]([[email protected]](CC)C)C(N[[email protected]@H](CCCCN(CC)CC)C(N[[email protected]@H](CO)C(NC#C)=O)=O)=O)=O)=O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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SW2_152F
Cat. No.:
HY-147058
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