1. Epigenetics
  2. Histone Methyltransferase
  3. SW2_152F

SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a Kd of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro. SW2_152F is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

SW2_152F Chemical Structure

SW2_152F Chemical Structure

Size Price Stock Quantity
1 mg USD 500 In-stock
5 mg USD 1300 In-stock
10 mg USD 2100 In-stock
25 mg USD 4400 In-stock
50 mg USD 6950 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a Kd of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro[1]. SW2_152F is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Kd: 80 nM (chromobox 2 chromodomain)[1]

In Vitro

SW2_152F inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

935.37

Formula

C45H62Cl3N7O8

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC(Cl)=CC(C(N[C@@H](CC2=CC(Cl)=C(O)C=C2)C(N[C@@H](C3CCCC3)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN(CC)CC)C(N[C@@H](CO)C(NCC#C)=O)=O)=O)=O)=O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (187.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0691 mL 5.3455 mL 10.6910 mL
5 mM 0.2138 mL 1.0691 mL 2.1382 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.77%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0691 mL 5.3455 mL 10.6910 mL 26.7274 mL
5 mM 0.2138 mL 1.0691 mL 2.1382 mL 5.3455 mL
10 mM 0.1069 mL 0.5345 mL 1.0691 mL 2.6727 mL
15 mM 0.0713 mL 0.3564 mL 0.7127 mL 1.7818 mL
20 mM 0.0535 mL 0.2673 mL 0.5345 mL 1.3364 mL
25 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0691 mL
30 mM 0.0356 mL 0.1782 mL 0.3564 mL 0.8909 mL
40 mM 0.0267 mL 0.1336 mL 0.2673 mL 0.6682 mL
50 mM 0.0214 mL 0.1069 mL 0.2138 mL 0.5345 mL
60 mM 0.0178 mL 0.0891 mL 0.1782 mL 0.4455 mL
80 mM 0.0134 mL 0.0668 mL 0.1336 mL 0.3341 mL
100 mM 0.0107 mL 0.0535 mL 0.1069 mL 0.2673 mL
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SW2_152F Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SW2_152F
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HY-147058
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