Entpd1 - ectonucleoside triphosphate diphosphohydrolase 1 Gene

Also Known as Cd39; NTPDase-1; 2610206B08Rik; E130009M23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12495

Summary

Enables adenosine-diphosphatase activity and nucleoside-triphosphatase activity. Involved in ADP catabolic process. Acts upstream of or within G protein-coupled receptor signaling pathway; platelet activation; and purine ribonucleoside diphosphate catabolic process. Located in basement membrane. Is active in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Entpd1 Products (2)

mRNA Protein Name
NM_001304721.1 NP_001291650.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform 1
NM_009848.4 NP_033978.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP phosphatase activity IMP
IMP: Inferred from mutant phenotype
17502665 MGI
enables nucleoside diphosphate phosphatase activity IDA
IDA: Inferred from direct assay
11929769 MGI
enables ribonucleoside triphosphate phosphatase activity IDA
IDA: Inferred from direct assay
11929769 MGI
Biological Process GO Annotation Evidence References Source
involved in ADP catabolic process IMP
IMP: Inferred from mutant phenotype
17502665 MGI
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11929769 MGI
acts upstream of or within platelet activation IDA
IDA: Inferred from direct assay
11929769 MGI
acts upstream of or within purine ribonucleoside diphosphate catabolic process IDA
IDA: Inferred from direct assay
11929769 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
11929769 MGI
is active in external side of plasma membrane IMP
IMP: Inferred from mutant phenotype
17502665 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ectonucleoside triphosphate diphosphohydrolase 1

  • CD39 antigen

  • NTPDase 1

  • ecto-ATP diphosphohydrolase 1

  • ecto-ATPDase 1

  • ecto-ATPase 1

  • ectoapyrase

  • lymphoid cell activation antigen

Recombinant Entpd1 Proteins

Cat. No. Product Name Accession Purity
HY-P70727 CD39 Protein, Mouse (HEK293, His) P55772 (T38-I478) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72898 CD39 Protein, Mouse (sf9, His) P55772 (T38-I478) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990068 Perenostobart Inhibitor 97.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04395 ENTPD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18563 Entpd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25045 Entpd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992099 Afivastobart Inhibitor 99.36% Unkown
HY-P991701 Mebarase alfa Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Entpd1 NCBI NCBI:953