Cdh17 - cadherin 17 Gene

Also Known as HPT-1; HPT-1/LI

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12557

Summary

Enables proton-dependent oligopeptide secondary active transmembrane transporter activity. Involved in germinal center B cell differentiation; marginal zone B cell differentiation; and spleen development. Acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and oligopeptide transport. Located in cell surface and plasma membrane. Is expressed in several structures, including common bile duct; gut; spleen; trunk; and urogenital sinus. Orthologous to human CDH17 (Cadherin 17). [provided by Alliance of Genome Resources, Apr 2022]

Cdh17 Products (1)

mRNA Protein Name
NM_019753.4 NP_062727.1 cadherin-17 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10906147 MGI
enables proton-dependent oligopeptide secondary active transmembrane transporter activity IDA
IDA: Inferred from direct assay
8153632 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
15688343 MGI
NOT involved in T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
15688343 MGI
acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
10906147 MGI
involved in germinal center B cell differentiation IMP
IMP: Inferred from mutant phenotype
15688343 MGI
acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
10906147 MGI
involved in marginal zone B cell differentiation IMP
IMP: Inferred from mutant phenotype
15688343 MGI
acts upstream of or within oligopeptide transport IDA
IDA: Inferred from direct assay
8153632 MGI
involved in spleen development IMP
IMP: Inferred from mutant phenotype
15688343 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15688343 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15023525 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-17

  • BILL-cadherin

  • LI-cadherin

  • P130

  • liver-intestine cadherin

Recombinant Cdh17 Proteins

Cat. No. Product Name Accession Purity
HY-P77895 Cadherin-17 Protein, Mouse (HEK293, His) Q9R100 (F26-M786) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990730 Cabotamig Inhibitor 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10941A VSLRGDTRG acetate Activator 99.38% Unkown
HY-175615A RSL3-NH2 hydrochloride / Unkown
HY-175615 RSL3-NH2 / Unkown
HY-RS02327 CDH17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10941 VSLRGDTRG Activator / Unkown
HY-RS17169 Cdh17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23619 Cdh17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990363 Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) Inhibitor 99.28% Unkown
HY-P991728 Zarutatug Inhibitor 99.11% Unkown
HY-P991100 Anti-CDH17/Cadherin-17 Antibody (10C12) Inhibitor 99.29% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh17 NCBI NCBI:1015