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Cat. No.: HY-187637

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Govitecan

Govitecan is a topoisomerase I inhibitor and also a linker-payload compound for antibody-drug conjugates (ADCs), with SN-38 as its active component. Govitecan serves as the linker-drug moiety of ADCs targeting CDH17-expressing cancer cells. Govitecan acts as the cytotoxic payload component of ADCs targeting Trop-2. Govitecan can be used in research related to colorectal cancer, gastric cancer, pancreatic cancer, liver cancer, metastatic triple-negative breast cancer, and other conditions.

For research use only. We do not sell to patients.

CAS No.: 1918106-06-5
Formula: C₇₃H₉₉N₁₁O₂₂
Molecular Weight:1482.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Govitecan Chemical Structure

CAS No.: 1918106-06-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Topoisomerase Isoforms :

Chemical Information

CAS No. 1918106-06-5
Molecular Weight 1482.63
Formula C₇₃H₉₉N₁₁O₂₂
SMILES

O=C1N2C(C3C(C2)=C(C4=CC(O)=CC=C4N3)CC)=CC5=C1COC([C@@]5(CC)OC(OCC6=CC=C(C=C6)NC([C@H](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7C=C(N=N7)CNC(C8CCC(CC8)CN9C(C=CC9=O)=O)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu Q, et al. WO 2025/061181 A1. International Application Published under the Patent Cooperation Treaty (PCT). LEPU BIOPHARMA CO., LTD. International Publication Date: 27 March 2025. International Application No.: PCT/CN2024/120196. International Filing Date: 20 September 2024.

[2]. Bardia A, et al. Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer. The New England journal of medicine. 2021 Apr 22;384(16):1529-1541.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Govitecan

All Topoisomerase Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

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Govitecan Related Classifications

HY-187637 Related Classifications

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