Cenpa - centromere protein A Gene

Also Known as Cenp-A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12615

Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

Cenpa Products (5)

mRNA Protein Name
NM_001302129.1 NP_001289058.1 histone H3-like centromeric protein A isoform 2
NM_001302130.1 NP_001289059.1 histone H3-like centromeric protein A isoform 2
NM_001302131.1 NP_001289060.1 histone H3-like centromeric protein A isoform 2
NM_001302132.1 NP_001289061.1 histone H3-like centromeric protein A isoform 3
NM_007681.3 NP_031707.1 histone H3-like centromeric protein A isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within protein localization to chromosome, centromeric region IMP
IMP: Inferred from mutant phenotype
22516971 MGI
Cellular Component GO Annotation Evidence References Source
located in CENP-A containing chromatin IDA
IDA: Inferred from direct assay
14519686 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
22516971 MGI
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
15242786 MGI
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
15242786 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H3-like centromeric protein A

  • centromere autoantigen A

  • centrosomin A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02473 CENPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19662 Cenpa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26155 Cenpa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cenpa NCBI NCBI:1058