Cfl2 - cofilin 2, muscle Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12632

Summary

Enables actin filament binding activity. Involved in actin filament fragmentation and skeletal muscle tissue development. Acts upstream of or within actin filament organization; muscle cell cellular homeostasis; and sarcomere organization. Predicted to be located in Z disc. Predicted to be active in actin Cytoskeleton and cytoplasm. Is expressed in heart ventricle; limb musculature; myotome; and neural retinal epithelium. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Cfl2 Products (1)

mRNA Protein Name
NM_007688.2 NP_031714.1 cofilin-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
11809832 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament depolymerization IDA
IDA: Inferred from direct assay
24840128 MGI
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
11809832 MGI
acts upstream of or within actin filament depolymerization IGI
IGI: Inferred from genetic interaction
24840128 MGI
involved in actin filament fragmentation IDA
IDA: Inferred from direct assay
11809832 MGI
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
22343409 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
22343409 MGI
acts upstream of or within sarcomere organization IMP
IMP: Inferred from mutant phenotype
22343409 MGI
involved in skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
24598388 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cofilin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02569 CFL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19883 Cfl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26382 Cfl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfl2 NCBI NCBI:1073