Chek1 - checkpoint kinase 1 Gene

Also Known as Chk1; rad27

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12649

About Chek1

Chromosome 9: 36,619,778-36,638,361 reverse strand.GRCm39:CM001002.3

This gene has 8 transcripts (splice variants), 178 orthologues and is associated with 10 phenotypes. Biased expression in CNS E11.5 (RPKM 8.), liver E14 (RPKM 5.6) and 9 other tissues.

Summary

Enables histone kinase activity (H3-T11 specific). Involved in epigenetic maintenance of chromatin in transcription-competent conformation; regulation of histone H3-K9 acetylation; and regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in chromatin; nucleus; and replication fork. Is expressed in several structures, including adrenal medulla; early conceptus; gonad; gut; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Chek1 Products (4)

mRNA Protein Name
NM_001410206.1 NP_001397135.1 serine/threonine-protein kinase Chk1 isoform 3
NM_001410205.1 NP_001397134.1 serine/threonine-protein kinase Chk1 isoform 2
NM_007691.6 NP_031717.2 serine/threonine-protein kinase Chk1 isoform 1
NM_001410207.1 NP_001397136.1 serine/threonine-protein kinase Chk1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3T11 kinase activity IDA
IDA: Inferred from direct assay
18243098 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15364958 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
15364958 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
12529385 MGI
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
10859164 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
11790307 MGI
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
18243098 MGI
acts upstream of or within DNA repair IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
10859164 MGI
acts upstream of or within apoptotic process involved in development IMP
IMP: Inferred from mutant phenotype
10859163 MGI
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
18243098 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: Inferred from mutant phenotype
10859163 MGI
acts upstream of or within mitotic cell cycle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
10859163 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
18243098 MGI
acts upstream of or within nucleus organization IMP
IMP: Inferred from mutant phenotype
10859163 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21737879 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
21737879 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
18243098 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11555636 MGI
located in replication fork IDA
IDA: Inferred from direct assay
15364958 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chek1 Protein Structure

STKc_Chk1

STKc_Chk1: cd14069 (6 - 264)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk1

  • CHK1 checkpoint homolog

  • checkpoint kinase 1 homolog

  • rad27 homolog

Recombinant Chek1 Proteins

Cat. No. Product Name Accession Purity
HY-P74253 Chk1 Protein, Mouse (sf9, His-GST) O35280 (M1-T476) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-RS02616 CHEK1 Human Pre-designed siRNA Set A / Unkown
HY-173147 CDK2-IN-42 Inhibitor / Unkown
HY-N15249 4"-Isovalerylspiramycin I / Unkown
HY-RS02617 Chek1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS02618 Chek1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek1 NCBI NCBI:1111