Chil1 - chitinase-like 1 Gene

Also Known as Gp39; Brp39; Chi3l1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12654

Summary

Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of protein kinase B signaling; and positive regulation of protein phosphorylation. Located in endoplasmic reticulum. Is expressed in alimentary system; limb; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Chil1 Products (2)

mRNA Protein Name
NM_001374626.1 NP_001361555.1 chitinase-3-like protein 1 isoform 2 precursor
NM_007695.4 NP_031721.2 chitinase-3-like protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23972995 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of NF-kappaB-inducing kinase activity IDA
IDA: Inferred from direct assay
21546314 MGI
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
21546314 MGI
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
21546314 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
21546314 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21546314 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21546314 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chitinase-3-like protein 1

  • CGP-39

  • GP-39

  • YKL-40

  • breast regression protein 39

  • cartilage glycoprotein 39

  • chitinase 3-like 1

Chil1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Chi3l1 Q61362 Il13ra2 Mus musculus O88786
Anti Bait CoIP
23972995
Intra
Chi3l1 Q61362 Il13ra2 Mus musculus O88786
IF
23972995
Intra
Chi3l1 Q61362 Il13ra2 Mus musculus O88786
Confocal
23972995
Intra
Chi3l1 Q61362 Il13ra2 Mus musculus O88786
Y2H
23972995
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Chil1 Proteins

Cat. No. Product Name Accession Purity
HY-P76702 CHI3L1 Protein, Mouse (HEK293, His) Q61362-2 (Y22-A381) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16736 Chi3l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23173 Chi3l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown