IL-13Rα2
Interleukin-13 receptor alpha 2 (IL-13Rα2, CD213a2) is a high-affinity IL-13 binding protein that differs fundamentally from its sibling IL-13Rα1. It binds IL-13 with approximately 50-fold higher affinity, exists partly as a soluble decoy, and possesses an extremely short 17-amino-acid cytoplasmic tail lacking box 1 and STAT docking motifs, so it was long considered a pure decoy receptor. IL-13Rα2 is barely detectable in normal tissues but is strongly upregulated in glioblastoma, colorectal, ovarian, pancreatic and breast cancers, where it correlates with invasion, metastasis and poor prognosis. Newer work shows membrane IL-13Rα2 can signal in a TMEM219/ERK/AP-1-dependent manner promoting TGF-β production and fibrosis in asthma and liver disease. This restricted, tumor-selective expression has made IL-13Rα2 a premier target for tumor-specific delivery: IL-13 PE38 immunotoxins, bispecific antibodies and IL-13Rα2-directed CAR-T cells have reached clinical trials for glioblastoma.
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IL-13Rα2 Recombinant Proteins (9)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
