IL-13R alpha 2 Protein, Human (HEK293, His)

IL-13R alpha 2 Protein, functioning as a monomer, exhibits high-affinity binding exclusively to interleukin-13 (IL13) without interaction with interleukin-4 (IL4). This binding selectivity indicates a unique role and specificity for IL-13R alpha 2 in mediating cellular responses to IL13, emphasizing its importance in IL13-associated cellular processes. IL-13R alpha 2 Protein, Human (HEK293, His) is the recombinant human-derived IL-13R alpha 2 protein, expressed by HEK293, with C-His labeled tag. The total length of IL-13R alpha 2 Protein, Human (HEK293, His) is 316 a.a., with molecular weight of 46-50 kDa.

The IL-13R alpha 2 protein functions as a monomer with high affinity, specifically binding to interleukin-13 (IL13) but not to interleukin-4 (IL4). This selectivity in binding suggests a distinct role and specificity for IL-13R alpha 2 in mediating responses to IL13, highlighting its importance in cellular processes associated with this cytokine.

Measured by its ability to inhibit IL-13-dependent proliferation of TF-1 human erythroleukemic cells.The ED₅₀ for this effect is 0.053 μg/mL in the presence of 8 ng/mL recombinant human IL-13, corresponding to a specific activity is 1.880×10⁴ U/mg.

• 
  Measured by its ability to inhibit IL-13-dependent proliferation of TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is 0.053 μg/mL in the presence of 8 ng/mL recombinant human IL-13, corresponding to a specific activity is 1.880×10⁴ U/mg.

Human

HEK293

C-His

Q14627/NP_000631.1 (D27-L342)

3598  [NCBI]

46-50 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.