Chrm3 - cholinergic receptor, muscarinic 3, cardiac Gene

Predicted to enable several functions, including G protein-coupled acetylcholine receptor binding activity; G protein-coupled amine receptor activity; and acetylcholine binding activity. Acts upstream of or within several processes, including cholinergic synaptic transmission; positive regulation of smooth muscle contraction; and saliva secretion. Predicted to be located in asymmetric synapse; axon terminus; and basal plasma membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Apr 2022]