Clcn2 - chloride channel, voltage-sensitive 2 Gene

Also Known as Clc2; ClC-2; nmf240

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12724

Summary

Enables voltage-gated Chloride Channel activity. Acts upstream of or within cell differentiation involved in salivary gland development and retina development in camera-type eye. Predicted to be located in dendrite; perikaryon; and plasma membrane. Predicted to be part of Chloride Channel complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; gonad; hindlimb phalanx; notochord; and visual system. Used to study leukodystrophy. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Apr 2022]

Clcn2 Products (1)

mRNA Protein Name
NM_009900.2 NP_034030.2 chloride channel protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
22405205 MGI
enables voltage-gated chloride channel activity IMP
IMP: Inferred from mutant phenotype
11976342 MGI
enables voltage-gated monoatomic anion channel activity IDA
IDA: Inferred from direct assay
26666914 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within acinar cell differentiation IMP
IMP: Inferred from mutant phenotype
11976342 MGI
acts upstream of or within cell differentiation involved in salivary gland development IMP
IMP: Inferred from mutant phenotype
11976342 MGI
involved in chloride transport IMP
IMP: Inferred from mutant phenotype
20357128 MGI
involved in regulation of resting membrane potential IMP
IMP: Inferred from mutant phenotype
20357128 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
involved in stabilization of membrane potential IMP
IMP: Inferred from mutant phenotype
20357128 MGI
Cellular Component GO Annotation Evidence Références Source
located in astrocyte end-foot IDA
IDA: Inferred from direct assay
17567819 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16155254 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
17567819 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chloride channel protein 2

  • chloride channel 2

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-B0680 Lubiprostone (hemiketal) Activator 98.00% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02754 CLCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22442 Clcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28965 Clcn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clcn2 NCBI NCBI:1181