Col4a3 - collagen, type IV, alpha 3 Gene

Predicted to enable Integrin binding activity. Predicted to be an extracellular matrix structural constituent. Involved in cell surface receptor signaling pathway; glomerular basement membrane development; and negative regulation of angiogenesis. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in basement membrane. Part of Collagen type IV trimer. Is expressed in several structures, including cardiovascular system; eye; foregut; genitourinary system; and trachea. Used to study autosomal recessive Alport syndrome. Human ortholog(s) of this gene implicated in Alport syndrome; autosomal dominant Alport syndrome; autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A3 (Collagen type IV alpha 3 chain). [provided by Alliance of Genome Resources, Apr 2022]