Col5a1 - collagen, type V, alpha 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12831

Summary

An extracellular matrix structural constituent. Acts upstream of or within several processes, including circulatory system development; Collagen fibril organization; and tendon development. Located in basement membrane. Part of Collagen trimer. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; heart; and skeleton. Used to study Ehlers-Danlos syndrome classic type 1. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome classic type 1. Orthologous to human COL5A1 (Collagen type V alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col5a1 Products (1)

mRNA Protein Name
NM_015734.2 NP_056549.2 collagen alpha-1(V) chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix structural constituent IDA
IDA: Inferred from direct assay
15383546 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14676276 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
16492673 MGI
acts upstream of or within collagen fibril organization IGI
IGI: Inferred from genetic interaction
17029294 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
15383546 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
17029294 MGI
acts upstream of or within regulation of cellular component organization IMP
IMP: Inferred from mutant phenotype
15383546 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
15383546 MGI
acts upstream of or within tendon development IGI
IGI: Inferred from genetic interaction
21467034 MGI
acts upstream of or within tendon development IMP
IMP: Inferred from mutant phenotype
21467034 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
14676276 MGI
part of collagen trimer IDA
IDA: Inferred from direct assay
15383546 MGI
part of collagen trimer IMP
IMP: Inferred from mutant phenotype
16492673 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
17029294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(V) chain

  • alpha1(V) collagen

  • pro-alpha1(V) collagen

  • procollagen type V alpha 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02989 COL5A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20541 Col5a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27049 Col5a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col5a1 NCBI NCBI:1289