Col6a1 - collagen, type VI, alpha 1 Gene

Also Known as Col6a-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12833

Summary

Predicted to enable Collagen binding activity and platelet-derived growth factor binding activity. Acts upstream of or within cellular response to amino acid stimulus. Located in extracellular matrix and sarcolemma. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart and pericardium; and sensory organ. Used to study Bethlem myopathy and Ullrich congenital muscular dystrophy. Human ortholog(s) of this gene implicated in Ullrich congenital muscular dystrophy. Orthologous to human COL6A1 (Collagen type VI alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col6a1 Products (1)

mRNA Protein Name
NM_009933.4 NP_034063.1 collagen alpha-1(VI) chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23300779 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within 2-oxoglutarate metabolic process IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within apoptotic nuclear changes IMP
IMP: Inferred from mutant phenotype
14625552 MGI
acts upstream of or within apoptotic process IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
14625552 MGI
acts upstream of or within autophagy IMP
IMP: Inferred from mutant phenotype
21037586 MGI
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
25158062 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
22448243 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
19248115 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
25989472 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
19248115 MGI
acts upstream of or within caveola assembly IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within cell death IMP
IMP: Inferred from mutant phenotype
28043812 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
24302007 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within circadian rhythm IMP
IMP: Inferred from mutant phenotype
26945058 MGI
acts upstream of or within collagen fibril organization IGI
IGI: Inferred from genetic interaction
28604699 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
25158062 MGI
acts upstream of or within collagen metabolic process IMP
IMP: Inferred from mutant phenotype
22343710 MGI
acts upstream of or within energy homeostasis IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within energy reserve metabolic process IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within fat cell proliferation IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within glycolytic process IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within hair follicle development IDA
IDA: Inferred from direct assay
25989472 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
25989472 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
22343710 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
28043812 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28043812 MGI
acts upstream of or within limb joint morphogenesis IMP
IMP: Inferred from mutant phenotype
22448243 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
31837950 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
24357721 MGI
acts upstream of or within lung epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
31837950 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
31837950 MGI
acts upstream of or within metabolic process IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within mitochondrial depolarization IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
19519726 MGI
acts upstream of or within mitochondrial transmembrane transport IMP
IMP: Inferred from mutant phenotype
19519726 MGI
acts upstream of or within mitochondrion organization IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
14625552 MGI
acts upstream of or within multicellular organismal locomotion IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19519726 MGI
acts upstream of or within muscle cell development IMP
IMP: Inferred from mutant phenotype
20716577 MGI
acts upstream of or within muscle organ development IMP
IMP: Inferred from mutant phenotype
26945058 MGI
acts upstream of or within muscle structure development IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within muscle system process IMP
IMP: Inferred from mutant phenotype
24852368 MGI
acts upstream of or within myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
24277578 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
24277578 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: Inferred from direct assay
21459131 MGI
acts upstream of or within organelle organization IMP
IMP: Inferred from mutant phenotype
21037586 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
19248115 MGI
acts upstream of or within peripheral nervous system development IMP
IMP: Inferred from mutant phenotype
24277578 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
21459131 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
26565691 MGI
acts upstream of or within protein lipidation IMP
IMP: Inferred from mutant phenotype
26565691 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within protein tetramerization IDA
IDA: Inferred from direct assay
23300779 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
20716577 MGI
acts upstream of or within reduction of food intake in response to dietary excess IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within regulation of cell size IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within regulation of collagen fibril organization IMP
IMP: Inferred from mutant phenotype
20951202 MGI
acts upstream of or within respiratory system process IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within response to UV IDA
IDA: Inferred from direct assay
21459131 MGI
acts upstream of or within response to activity IMP
IMP: Inferred from mutant phenotype
24357721 MGI
acts upstream of or within response to bleomycin IMP
IMP: Inferred from mutant phenotype
25158062 MGI
acts upstream of or within response to decreased oxygen levels IMP
IMP: Inferred from mutant phenotype
22343710 MGI
acts upstream of or within response to lipid IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19114551 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
19248115 MGI
acts upstream of or within response to muscle activity IMP
IMP: Inferred from mutant phenotype
22024752 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
24277578 MGI
acts upstream of or within response to peptide IMP
IMP: Inferred from mutant phenotype
24852368 MGI
acts upstream of or within response to polyamine macromolecule IMP
IMP: Inferred from mutant phenotype
26565691 MGI
acts upstream of or within response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
20716577 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within response to wounding IDA
IDA: Inferred from direct assay
25989472 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
22343710 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
19519726 MGI
acts upstream of or within sensory perception of mechanical stimulus IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within single fertilization IGI
IGI: Inferred from genetic interaction
28604699 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
21037586 MGI
acts upstream of or within skeletal muscle fiber differentiation IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within skeletal muscle organ development IMP
IMP: Inferred from mutant phenotype
26565691 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
19248115 MGI
acts upstream of or within skeletal muscle tissue growth IMP
IMP: Inferred from mutant phenotype
28043812 MGI
acts upstream of or within skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
28043812 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
25158062 MGI
acts upstream of or within tissue remodeling IMP
IMP: Inferred from mutant phenotype
22343710 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
24277578 MGI
acts upstream of or within tricarboxylic acid cycle IMP
IMP: Inferred from mutant phenotype
23437220 MGI
acts upstream of or within uterus development IGI
IGI: Inferred from genetic interaction
28604699 MGI
Cellular Component GO Annotation Evidence References Source
is active in basement membrane IDA
IDA: Inferred from direct assay
31837950 MGI
is active in extracellular matrix IDA
IDA: Inferred from direct assay
19248115 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
8806434 MGI
is active in extracellular matrix IMP
IMP: Inferred from mutant phenotype
20951202 MGI
is active in intracellular vesicle IDA
IDA: Inferred from direct assay
24357721 MGI
is active in lysosome IDA
IDA: Inferred from direct assay
28604699 MGI
is active in myofibril IMP
IMP: Inferred from mutant phenotype
20716577 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
16810681 MGI
is active in sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
22024752 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(VI) chain

  • procollagen, type VI, alpha 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02992 COL6A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19250 Col6a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25739 Col6a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col6a1 NCBI NCBI:1291