Coq7 - demethyl-Q 7 Gene

Also Known as clk-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12850

Summary

Predicted to enable 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity and chromatin binding activity. Acts upstream of or within several processes, including age-dependent response to oxidative stress; chordate embryonic development; and mitochondrion morphogenesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; ear; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 8. Orthologous to human COQ7 (coenzyme Q7, hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Coq7 Products (4)

mRNA Protein Name
NM_001304758.2 NP_001291687.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform 2
NM_001412267.1 NP_001399196.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform 3
NM_001412268.1 NP_001399197.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform 4
NM_009940.4 NP_034070.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
18635541 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
19478076 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
11585841 MGI
acts upstream of or within mitochondrial ATP synthesis coupled electron transport IMP
IMP: Inferred from mutant phenotype
18635541 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
11716496 MGI
acts upstream of or within neural tube formation IMP
IMP: Inferred from mutant phenotype
11716496 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
11716496 MGI
acts upstream of or within respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
11585841 MGI
acts upstream of or within response to oxidative stress IGI
IGI: Inferred from genetic interaction
19478076 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
19478076 MGI
NOT acts upstream of or within ubiquinone biosynthetic process IMP
IMP: Inferred from mutant phenotype
19478076 MGI
acts upstream of or within ubiquinone biosynthetic process IMP
IMP: Inferred from mutant phenotype
11585841 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5-demethoxyubiquinone hydroxylase, mitochondrial

  • DMQ hydroxylase

  • coenzyme Q biosynthesis protein 7 homolog

  • timing protein clk-1 homolog

  • ubiquinone biosynthesis monooxygenase COQ7

  • ubiquinone biosynthesis protein COQ7 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133033 COQ7-IN-1 Inhibitor 99.55% Unkown
HY-138429 COQ7-IN-2 Inhibitor 99.74% Unkown
HY-RS03043 COQ7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18468 Coq7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24949 Coq7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Coq7 NCBI NCBI:10229