Crhr2 - corticotropin releasing hormone receptor 2 Gene

Also Known as Crfr2; CRF-R2; CRFR2beta; CRFR2alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12922

About Crhr2

Chromosome 6: 55,067,034-55,110,001 reverse strand.GRCm39:CM000999.3

This gene has 9 transcripts (splice variants), 203 orthologues, 41 paralogues and is associated with 24 phenotypes. Biased expression in heart adult (RPKM 14.2), mammary gland adult (RPKM 3.1) and 2 other tissues.

Summary

Enables corticotrophin-releasing factor receptor activity and hormone activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of angiogenesis; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in Golgi apparatus; cell surface; and endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Crhr2 Products (4)

mRNA Protein Name
NM_009953.4 NP_034083.2 corticotropin-releasing factor receptor 2 isoform 2 precursor
NM_001288619.1 NP_001275548.1 corticotropin-releasing factor receptor 2 isoform 3 precursor
NM_001288620.1 NP_001275549.1 corticotropin-releasing factor receptor 2 isoform 4
NM_001288618.1 NP_001275547.1 corticotropin-releasing factor receptor 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables corticotrophin-releasing factor receptor activity IDA
IDA: Inferred from direct assay
12032352 MGI
enables hormone activity IDA
IDA: Inferred from direct assay
15514029 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15514029 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15514029 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
12032352 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Crhr2 Protein Structure

HormR

HormR: smart00008 (55 - 126)

7tm_GPCRs

7tm_GPCRs: cl28897 (132 - 395)

7tm_GPCRs

7tm_GPCRs: cd14964 (135 - 159)

7tm_GPCRs

7tm_GPCRs: cd14964 (168 - 189)

7tm_GPCRs

7tm_GPCRs: cd14964 (204 - 226)

7tm_GPCRs

7tm_GPCRs: cd14964 (245 - 261)

7tm_GPCRs

7tm_GPCRs: cd14964 (280 - 303)

7tm_GPCRs

7tm_GPCRs: cd14964 (328 - 350)

7tm_GPCRs

7tm_GPCRs: cd14964 (357 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

corticotropin-releasing factor receptor 2

  • CRF 2 receptor

  • CRF-R-2

  • CRF-RB

  • CRFR-2

  • CRH-R-2

  • CRH-R2

  • corticotropin releasing factor receptor type 2 beta

  • corticotropin-releasing factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3684A [DPro5] Corticotropin Releasing Factor, human, rat TFA Agonist 98.71% Unkown
HY-RS03171 CRHR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03172 Crhr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03173 Crhr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crhr2 NCBI NCBI:1395