2. Gene
  3. Crhr2 - corticotropin releasing hormone receptor 2 Gene

Crhr2 - corticotropin releasing hormone receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Crfr2; CRF-R2; CRFR2beta; CRFR2alpha

Gene ID: 12922 | Gene type: protein coding

About Crhr2

Chromosome 6: 55,067,034-55,110,001 reverse strand.GRCm39:CM000999.3

This gene has 9 transcripts (splice variants), 203 orthologues, 41 paralogues and is associated with 24 phenotypes. Biased expression in heart adult (RPKM 14.2), mammary gland adult (RPKM 3.1) and 2 other tissues.

Summary

Enables corticotrophin-releasing factor receptor activity and hormone activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of angiogenesis; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in Golgi apparatus; cell surface; and endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Crhr2 Products(4)

mRNA Protein Name
NM_009953.4 NP_034083.2 corticotropin-releasing factor receptor 2 isoform 2 precursor
NM_001288619.1 NP_001275548.1 corticotropin-releasing factor receptor 2 isoform 3 precursor
NM_001288620.1 NP_001275549.1 corticotropin-releasing factor receptor 2 isoform 4
NM_001288618.1 NP_001275547.1 corticotropin-releasing factor receptor 2 isoform 1 precursor

Crhr2 Protein Structure

HormR

HormR: smart00008 (55 - 126)

7tm_GPCRs

7tm_GPCRs: cl28897 (132 - 395)

7tm_GPCRs

7tm_GPCRs: cd14964 (135 - 159)

7tm_GPCRs

7tm_GPCRs: cd14964 (168 - 189)

7tm_GPCRs

7tm_GPCRs: cd14964 (204 - 226)

7tm_GPCRs

7tm_GPCRs: cd14964 (245 - 261)

7tm_GPCRs

7tm_GPCRs: cd14964 (280 - 303)

7tm_GPCRs

7tm_GPCRs: cd14964 (328 - 350)

7tm_GPCRs

7tm_GPCRs: cd14964 (357 - 382)

  • 0
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  • 431 a.a.
Protein Preferred Names Protein Names

corticotropin-releasing factor receptor 2

CRF 2 receptor

CRF-R-2

CRF-RB

CRFR-2

CRH-R-2

CRH-R2

corticotropin releasing factor receptor type 2 beta

corticotropin-releasing factor 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3684A [DPro5] Corticotropin Releasing Factor, human, rat TFA Agonist 99.71% Unkown
HY-RS03171 CRHR2 Human Pre-designed siRNA Set A / Unkown
HY-RS03172 Crhr2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS03173 Crhr2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crhr2 NCBI NCBI:1395