2. Gene
  3. Ctss - cathepsin S Gene

Ctss - cathepsin S Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cats

Gene ID: 13040 | Gene type: protein coding

About Ctss

Chromosome 3: 95,434,097-95,463,714 forward strand.GRCm39:CM000996.3

This gene has 2 transcripts (splice variants), 270 orthologues, 24 paralogues and is associated with 21 phenotypes. Broad expression in spleen adult (RPKM 32.7), large intestine adult (RPKM 28.4) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This Enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic Cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]

Ctss Products(2)

mRNA Protein Name
NM_001267695.2 NP_001254624.2 cathepsin S isoform 1 preproprotein
NM_021281.3 NP_067256.4 cathepsin S isoform 2 preproprotein

Ctss Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (35 - 94)

Peptidase_C1

Peptidase_C1: pfam00112 (122 - 337)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

cathepsin S

Cat S

Recombinant Ctss Proteins

Cat. No. Product Name Accession Purity
HY-P7757 Cathepsin S Protein, Mouse (HEK293, His) O70370 (V18-I340) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-E70226 Cathepsin S, human / Unkown
HY-RS03344 CTSS Human Pre-designed siRNA Set A / Unkown
HY-RS03345 Ctss Mouse Pre-designed siRNA Set A / Unkown
HY-RS03346 Ctss Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctss NCBI NCBI:1520