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Cxadr - coxsackie virus and adenovirus receptor Gene

Also Known as CAR; MCAR; MCVADR; 2610206D03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13052

Summary

This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Cxadr Products (3)

mRNA	Protein	Name
NM_001025192.3	NP_001020363.1	coxsackievirus and adenovirus receptor homolog isoform a precursor
NM_001276263.1	NP_001263192.1	coxsackievirus and adenovirus receptor homolog isoform c precursor
NM_009988.4	NP_034118.1	coxsackievirus and adenovirus receptor homolog isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	18636119	MGI
enables connexin binding	IPI IPI: Inferred from physical interaction	18636119	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15979067	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in AV node cell to bundle of His cell communication	IMP IMP: Inferred from mutant phenotype	18636119	MGI
involved in AV node cell-bundle of His cell adhesion involved in cell communication	IMP IMP: Inferred from mutant phenotype	18636119	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	16079292	MGI
acts upstream of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16543498	MGI
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	10814828	MGI
acts upstream of or within cell-cell junction organization	IMP IMP: Inferred from mutant phenotype	16543498	MGI
involved in gamma-delta T cell activation	IDA IDA: Inferred from direct assay	20813954	MGI
involved in germ cell migration	IEP IEP: Inferred from expression pattern	17690169	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15864812	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	16079292	MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16543498	MGI
involved in regulation of AV node cell action potential	IMP IMP: Inferred from mutant phenotype	18636119	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	31043663	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	31043663	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	27629708	MGI
is active in GABA-ergic synapse	IEP IEP: Inferred from expression pattern	27629708	MGI
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	16410001	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11316797	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	17690169	MGI
located in cell body	IDA IDA: Inferred from direct assay	10814828	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	16678988	MGI
located in filopodium	IDA IDA: Inferred from direct assay	10814828	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27629708	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	27629708	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	31043663	MGI
located in growth cone	IDA IDA: Inferred from direct assay	10814828	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	18636119	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	10814828	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	27629708	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	27629708	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
coxsackievirus and adenovirus receptor homolog

Recombinant Cxadr Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70052	CXADR Protein, Mouse (HEK293, Fc)	P97792 (L20-G237)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72364	CXADR Protein, Mouse (Biotinylated, HEK293, Avi-His)	P97792 (L20-G237)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16275	Cxadr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03382	CXADR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23594	Cxadr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cxadr	NCBI	NCBI:1525