Cyp17a1 - cytochrome P450, family 17, subfamily a, polypeptide 1 Gene

Also Known as Cyp17; p450c17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13074

Summary

Enables steroid 17-alpha-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in axon and neuronal cell body. Is expressed in several structures, including adrenal gland; gut; nervous system; reproductive system; and retina layer. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate Cancer. Orthologous to human CYP17A1 (Cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp17a1 Products (1)

mRNA Protein Name
NM_007809.3 NP_031835.3 steroid 17-alpha-hydroxylase/17,20 lyase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables steroid 17-alpha-monooxygenase activity IDA
IDA: Inferred from direct assay
6090441 MGI
enables steroid 17-alpha-monooxygenase activity IMP
IMP: Inferred from mutant phenotype
15169901 MGI
Biological Process GO Annotation Evidence References Source
involved in androgen biosynthetic process IDA
IDA: Inferred from direct assay
6090441 MGI
involved in androgen biosynthetic process IMP
IMP: Inferred from mutant phenotype
15169901 MGI
acts upstream of or within glucocorticoid biosynthetic process IDA
IDA: Inferred from direct assay
7588219 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
7588260 MGI
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
26819663 MGI
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
26819663 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
7588260 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

steroid 17-alpha-hydroxylase/17,20 lyase

  • 17-alpha-hydroxyprogesterone aldolase

  • CYPXVII

  • cytochrome P450 17A1

  • cytochrome P450, 17

  • cytochrome P450, 17a1

  • cytochrome P450-C17

  • cytochrome P450c17

  • steroid 17-alpha hydroxylase

  • steroid 17-alpha-monooxygenase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-164457 ASN-001 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148430 4-Pyridylmethyl adamantanecarboxamide Inhibitor 99.83% Unkown
HY-181045 CYP17A1-IN-2 Inhibitor / Unkown
HY-163359 CYP17A1/HDAC6-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp17a1 NCBI NCBI:1586