Cyp46a1 - cytochrome P450, family 46, subfamily a, polypeptide 1 Gene

Also Known as CH24H; Cyp46

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13116

Summary

Enables Cholesterol 24-hydroxylase activity. Involved in Cholesterol catabolic process and regulation of long-term synaptic potentiation. Acts upstream of with a negative effect on protein localization to membrane raft. Located in several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina nuclear layer; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (Cytochrome P450 family 46 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp46a1 Products (1)

mRNA Protein Name
NM_010010.3 NP_034140.1 cholesterol 24-hydroxylase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholesterol 24-hydroxylase activity IDA
IDA: Inferred from direct assay
10377398 MGI
Biological Process GO Annotation Evidence References Source
involved in cholesterol catabolic process IDA
IDA: Inferred from direct assay
10377398 MGI
acts upstream of negative effect protein localization to membrane raft IDA
IDA: Inferred from direct assay
20193040 MGI
involved in regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
16505352 MGI
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
18241055 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
18241055 MGI
located in postsynapse IDA
IDA: Inferred from direct assay
16505352 MGI
located in presynapse IDA
IDA: Inferred from direct assay
16505352 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cholesterol 24-hydroxylase

  • cholesterol 24-monooxygenase

  • cholesterol 24S-hydroxylase

  • cholestrol 24-hydroxylase

  • cytochrome P450, 46a1 (cholesterol 24-hydroxylase)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109123 Soticlestat Inhibitor 99.83% Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-144309 Cholesterol 24-hydroxylase-IN-1 Inhibitor 99.55% Unkown
HY-156799 Cholesterol 24-hydroxylase-IN-2 Inhibitor / Unkown
HY-172205 CHL2310 Inhibitor / Unkown
HY-RS03475 CYP46A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18437 Cyp46a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24919 Cyp46a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp46a1 NCBI NCBI:10858