1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Cholesterol 24-hydroxylase-IN-1

Cholesterol 24-hydroxylase-IN-1 

Cat. No.: HY-144309 Purity: 99.53%
COA Handling Instructions

Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier.

For research use only. We do not sell to patients.

Cholesterol 24-hydroxylase-IN-1 Chemical Structure

Cholesterol 24-hydroxylase-IN-1 Chemical Structure

CAS No. : 1613480-70-8

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100 mg USD 1420 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier[1].

Molecular Weight

313.40

Formula

C17H23N5O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCN(C2=C(N3N=CC(C)=C3)C=CN=C2)CC1)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (319.08 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1908 mL 15.9541 mL 31.9081 mL
5 mM 0.6382 mL 3.1908 mL 6.3816 mL
10 mM 0.3191 mL 1.5954 mL 3.1908 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.53%

References
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Cholesterol 24-hydroxylase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Cholesterol 24-hydroxylase-IN-1
Cat. No.:
HY-144309
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