Cyp8b1 - cytochrome P450, family 8, subfamily b, polypeptide 1 Gene
Species: Mus musculus
Summary
Predicted to enable sterol 12-alpha-hydroxylase activity. Involved in bile acid biosynthetic process and positive regulation of intestinal Cholesterol absorption. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including liver; lung; skeletal muscle; spleen; and testis. Orthologous to human CYP8B1 (Cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Cyp8b1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_010012.3 | NP_034142.3 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in bile acid biosynthetic process |
IMP
IMP: Inferred from mutant phenotype
|
12393855 | MGI |
| involved in positive regulation of intestinal cholesterol absorption |
IDA
IDA: Inferred from direct assay
|
12393855 | MGI |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-113259 | 7α-Hydroxy-4-cholesten-3-one | 99.60% | Unkown | |
| HY-113259S | 7α-Hydroxy-4-cholesten-3-one-d7 | ≥98.0% | Unkown | |
| HY-113259R | 7α-Hydroxy-4-cholesten-3-one (Standard) | / | Unkown | |
| HY-183692 | FXR agonist 18 | / | Unkown | |
| HY-RS03489 | CYP8B1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS17779 | Cyp8b1 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS24246 | Cyp8b1 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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