Dab1 - disabled 1 Gene

Also Known as scm; scr; yot; scrambler; C630028C02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13131

Summary

Predicted to enable phosphatidylinositol 3-kinase binding activity. Involved in lateral motor column neuron migration. Acts upstream of or within several processes, including adult walking behavior; negative regulation of receptor signaling pathway via JAK-STAT; and nervous system development. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dab1 Products (6)

mRNA Protein Name
NM_001369046.1 NP_001355975.1 disabled homolog 1 isoform 2
NM_001369047.1 NP_001355976.1 disabled homolog 1 isoform 2
NM_001369048.1 NP_001355977.1 disabled homolog 1 isoform 3
NM_001369049.1 NP_001355978.1 disabled homolog 1 isoform 4
NM_010014.3 NP_034144.1 disabled homolog 1 isoform 1
NM_177259.4 NP_796233.2 disabled homolog 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10460257 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
9009273 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Golgi localization IMP
IMP: Inferred from mutant phenotype
21111240 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
8875886 MGI
acts upstream of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18848628 MGI
acts upstream of axonogenesis IGI
IGI: Inferred from genetic interaction
21111240 MGI
acts upstream of axonogenesis IMP
IMP: Inferred from mutant phenotype
21111240 MGI
acts upstream of cell adhesion IMP
IMP: Inferred from mutant phenotype
15091337 MGI
acts upstream of cell surface receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
18848628 MGI
acts upstream of or within cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration IMP
IMP: Inferred from mutant phenotype
15091337 MGI
acts upstream of or within cerebellum structural organization IMP
IMP: Inferred from mutant phenotype
9338785 MGI
acts upstream of or within cerebral cortex cell migration IMP
IMP: Inferred from mutant phenotype
15249135 MGI
acts upstream of or within cerebral cortex radially oriented cell migration IGI
IGI: Inferred from genetic interaction
24210661 MGI
acts upstream of or within cerebral cortex radially oriented cell migration IMP
IMP: Inferred from mutant phenotype
9338785 MGI
involved in cerebral cortex radially oriented cell migration IMP
IMP: Inferred from mutant phenotype
9338784 MGI
acts upstream of or within dendrite development IGI
IGI: Inferred from genetic interaction
14715136 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
14715136 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
18477607 MGI
involved in lateral motor column neuron migration IMP
IMP: Inferred from mutant phenotype
20711475 MGI
acts upstream of or within motor neuron migration IMP
IMP: Inferred from mutant phenotype
15703280 MGI
acts upstream of or within negative regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18848628 MGI
acts upstream of or within negative regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
21111240 MGI
acts upstream of or within negative regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
21111240 MGI
acts upstream of or within negative regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
15091337 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
18848628 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
18848628 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
11226314 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
8875886 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
9338784 MGI
acts upstream of or within positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
18848628 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: Inferred from genetic interaction
12526740 MGI
acts upstream of or within radial glia guided migration of Purkinje cell IGI
IGI: Inferred from genetic interaction
24210661 MGI
acts upstream of or within radial glia guided migration of Purkinje cell IMP
IMP: Inferred from mutant phenotype
9338785 MGI
involved in radial glia guided migration of Purkinje cell IMP
IMP: Inferred from mutant phenotype
9338784 MGI
acts upstream of or within radial glia-guided pyramidal neuron migration IMP
IMP: Inferred from mutant phenotype
9338785 MGI
involved in reelin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
9338784 MGI
involved in regulation of synapse maturation IDA
IDA: Inferred from direct assay
27624722 MGI
involved in regulation of synapse maturation IMP
IMP: Inferred from mutant phenotype
27624722 MGI
acts upstream of or within small GTPase-mediated signal transduction IMP
IMP: Inferred from mutant phenotype
15062102 MGI
involved in ventral spinal cord development IEP
IEP: Inferred from expression pattern
20711475 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
9338785 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24068831 MGI
located in perinuclear region of cytoplasm IGI
IGI: Inferred from genetic interaction
14578885 MGI
is active in synapse IDA
IDA: Inferred from direct assay
24068831 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disabled homolog 1

  • yotari

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03510 DAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03840 DNAAF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09781 OMA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19317 Dab1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25808 Dab1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dab1 NCBI NCBI:1600