Gadd45a - growth arrest and DNA-damage-inducible 45 alpha Gene

Also Known as Ddit1; GADD45

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13197

Summary

Enables promoter-specific chromatin binding activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and negative regulation of peptidyl-serine phosphorylation of STAT protein. Acts upstream of or within centrosome cycle; negative regulation of protein kinase activity; and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; sensory organ; and tibialis anterior. Used to study systemic lupus erythematosus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gadd45a Products (1)

mRNA Protein Name
NM_007836.1 NP_031862.1 growth arrest and DNA damage-inducible protein GADD45 alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22323595 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12124778 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within centrosome cycle IGI
IGI: Inferred from genetic interaction
15123655 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
23329839 MGI
involved in negative regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
23329839 MGI
involved in negative regulation of peptidyl-serine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
23329839 MGI
acts upstream of or within negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
12124778 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
12124778 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19796622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth arrest and DNA damage-inducible protein GADD45 alpha

  • DDIT-1

  • DNA damage-inducible transcript 1 protein

  • DNA-damage-inducible transcript 1

  • Gadd45alpha

  • growth arrest and DNA-damage-inducible, alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10587 BIX-01294 98.44% Unkown
HY-108239 BIX-01294 trihydrochloride 99.68% Unkown
HY-RS05229 GADD45A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-136893 SP-6-27 / Unkown
HY-RS17861 Gadd45a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24330 Gadd45a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gadd45a NCBI NCBI:1647