Dgat1 - diacylglycerol O-acyltransferase 1 Gene

Also Known as ARAT; Dgat; D15Ertd23e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13350

Summary

Enables 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Involved in several processes, including acylglycerol metabolic process; fatty acid homeostasis; and long-chain fatty-acyl-CoA metabolic process. Located in intracellular membrane-bounded organelle and membrane. Is integral component of membrane. Is expressed in several structures, including brain; genitourinary system; integument; liver; and yolk sac. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dgat1 Products (1)

mRNA Protein Name
NM_010046.4 NP_034176.1 diacylglycerol O-acyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-acylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
12077311 MGI
enables diacylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
11481335 MGI
Biological Process GO Annotation Evidence References Source
involved in diacylglycerol metabolic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in fatty acid homeostasis IGI
IGI: Inferred from genetic interaction
18252207 MGI
involved in fatty acid homeostasis IMP
IMP: Inferred from mutant phenotype
10802663 MGI
involved in lipid storage IGI
IGI: Inferred from genetic interaction
21317108 MGI
involved in lipid storage IMP
IMP: Inferred from mutant phenotype
10802663 MGI
involved in long-chain fatty-acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in monoacylglycerol biosynthetic process IMP
IMP: Inferred from mutant phenotype
28420705 MGI
involved in triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
11481335 MGI
involved in triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
10802663 MGI
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
19049983 MGI
located in intracellular membrane-bounded organelle IMP
IMP: Inferred from mutant phenotype
18252207 MGI
located in membrane IDA
IDA: Inferred from direct assay
10802663 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

diacylglycerol O-acyltransferase 1

  • acyl-CoA retinol O-fatty-acyltransferase

  • diglyceride acyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N16614 Ent-Calquiquelignan E Inhibitor / Unkown
HY-153507 DGAT1-IN-4 Inhibitor / Unkown
HY-185926 Idalaptican pegol Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dgat1 NCBI NCBI:8694