DGAT1 - diacylglycerol O-acyltransferase 1 Gene

Also Known as ARAT; DGAT; ARGP1; DIAR7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8694

About DGAT1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,314,584-144,326,852 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 262 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in small intestine (RPKM 98.7), duodenum (RPKM 96.5) and 20 other tissues.

Summary

This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and Other metabolic diseases. [provided by RefSeq, Jul 2013]

DGAT1 Products (1)

mRNA	Protein	Name
NM_012079.6	NP_036211.2	diacylglycerol O-acyltransferase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables diacylglycerol O-acyltransferase activity	IDA IDA: Inferred from direct assay	18458083	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32433610	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23420847	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in diacylglycerol metabolic process	IDA IDA: Inferred from direct assay	32433610	GOA
involved in monoacylglycerol biosynthetic process	IDA IDA: Inferred from direct assay	28420705	GOA
acts upstream of or within triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	18458083	GOA
involved in triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	18238778	GOA
involved in very-low-density lipoprotein particle assembly	IMP IMP: Inferred from mutant phenotype	15308631	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in membrane	IDA IDA: Inferred from direct assay	32433610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGAT1 Protein Structure

MBOAT

0
100
200
300
400
488 a.a.

Protein Preferred Names	Protein Names
diacylglycerol O-acyltransferase 1	ACAT related gene product 1

DGAT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DGAT1	O75907	DGAT1	Homo sapiens	O75907	3D-EM	32433610
Intra	DGAT1	O75907	GABRA4	Homo sapiens	P48169	Y2H Array	21988832
Intra	DGAT1	O75907	DGAT1	Homo sapiens	O75907	GMS	32433610
Intra	DGAT1	O75907	CCR9	Homo sapiens	P51686	Ub Reconstruction	28298427
Intra	DGAT1	O75907	DGAT1	Homo sapiens	O75907	3D-EM	32433611

Cross: Cross-species interaction Intra: Intraspecies interaction

DGAT1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81246	DGAT1 Antibody (YA3508)	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Congenital Diarrhea 7 With Exudative Enteropathy	Congenital Chronic Diarrhea With Exudative Enteropathy Congenital Chronic Diarrhea With Protein-Losing Enteropathy Congenital Chronic Diarrhoea With Exudative Enteropathy Congenital Chronic Diarrhoea With Protein-Losing Enteropathy Congenital Diarrhoea 7 With Exudative Enteropathy
Diarrhea 7, Protein-Losing Enteropathy Type	DIAR7
Protein-Losing Enteropathy	Protein-Losing Enteropathies Enteropathy, Exudative Exudative Enteropathy Ple - [Protein-Losing Enteropathy]
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Hyperlipoproteinemia, Type I	Lipoprotein Lipase Deficiency Familial Chylomicronemia Syndrome Lpl Deficiency Hyperchylomicronemia, Familial Hyperlipemia, Idiopathic, Burger-Grutz Type Hyperlipemia, Essential Familial Lipase D Deficiency Lipd Deficiency Hyperlipoproteinemia, Type Ia Chylomicronemia, Familial High Density Lipoprotein Cholesterol Level Qtl 11 Hyperlipoproteinemia Type 1 Hyperlipoproteinemia 1 HLPP1 Lipoprotein Lipase Hyperlipoproteinemia Type I Familial Hyperchylomicronemia Syndrome
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Congenital Diarrhea
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-153507	DGAT1-IN-4	Inhibitor	/	Unkown
HY-N16614	Ent-Calquiquelignan E	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DGAT1	VGNC	VGNC:61455
Rattus norvegicus	DGAT1	RGD	RGD:628673
Macaca mulatta	DGAT1	VGNC	VGNC:71776
Canis familiaris	DGAT1	VGNC	VGNC:39912
Mus musculus	DGAT1	MGD	MGI:1333825
Bos taurus	DGAT1	VGNC	VGNC:28020
Others	DGAT1	NCBI