Dhcr7 - 7-dehydrocholesterol reductase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13360

Summary

Enables 7-dehydrocholesterol reductase activity. Acts upstream of or within several processes, including blood vessel development; lung development; and sterol biosynthetic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in adrenal gland; genitourinary system; and neural retina. Used to study Smith-Lemli-Opitz syndrome. Human ortholog(s) of this gene implicated in Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Apr 2022]

Dhcr7 Products (12)

mRNA Protein Name
NM_001382498.2 NP_001369427.1 7-dehydrocholesterol reductase isoform 1
NM_001382499.1 NP_001369428.1 7-dehydrocholesterol reductase isoform 2
NM_001382500.1 NP_001369429.1 7-dehydrocholesterol reductase isoform 3
NM_001382501.2 NP_001369430.1 7-dehydrocholesterol reductase isoform 4
NM_001382503.1 NP_001369432.1 7-dehydrocholesterol reductase isoform 1
NM_001412317.1 NP_001399246.1 7-dehydrocholesterol reductase isoform 1
NM_001412318.1 NP_001399247.1 7-dehydrocholesterol reductase isoform 1
NM_001412319.1 NP_001399248.1 7-dehydrocholesterol reductase isoform 1
NM_001412320.1 NP_001399249.1 7-dehydrocholesterol reductase isoform 4
NM_001412321.1 NP_001399250.1 7-dehydrocholesterol reductase isoform 3
NM_001412322.1 NP_001399251.1 7-dehydrocholesterol reductase isoform 5
NM_007856.2 NP_031882.1 7-dehydrocholesterol reductase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 7-dehydrocholesterol reductase activity IDA
IDA: Inferred from direct assay
11792727 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
15005800 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
15005800 MGI
acts upstream of or within lung epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
15005800 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
15005800 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
15005800 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15005800 MGI
acts upstream of or within sterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
15005800 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

7-dehydrocholesterol reductase

  • 7-DHC reductase

  • sterol Delta(7)-reductase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107420 AY 9944 99.67% Unkown
HY-164561 TASIN-30 99.96% Unkown
HY-Y0889 1-(2,3-Dichlorphenyl)piperazine 99.38% Unkown
HY-Y0889A 1-(2,3-Dichlorphenyl)piperazine hydrochloride 99.98% Unkown
HY-RS03727 DHCR7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107420S AY 9944-d8 / Unkown
HY-RS17300 Dhcr7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23755 Dhcr7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhcr7 NCBI NCBI:1717