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CPA2 - carboxypeptidase A2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1358

About CPA2

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,266,863-130,289,798 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 8 paralogues. Restricted expression toward pancreas (RPKM 5496.0).

Summary

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. [provided by RefSeq, Dec 2008]

CPA2 Products (1)

mRNA	Protein	Name
NM_001869.3	NP_001860.2	carboxypeptidase A2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carboxypeptidase activity	IDA IDA: Inferred from direct assay	2920728	GOA
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	2920728	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	2920728	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	2920728	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPA2 Protein Structure

Propep_M14

Peptidase_M14

0
100
200
300
400
419 a.a.

Protein Preferred Names	Protein Names
carboxypeptidase A2	carboxypeptidase A2 (pancreatic)

Recombinant CPA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7733	Carboxypeptidase A2/CPA2 Protein, Human (HEK293, His)	AAP36067.1 (L17-Y417)	≥ 95%, as determined by reducing SDS-PAGE.

CPA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82741	Carboxypeptidase A1/A2/B Antibody (YA2486)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myasthenic Syndrome, Congenital, 10	Congenital Myasthenic Syndrome 10 CMS10 Lgm Myasthenia, Limb-Girdle, Familial Myasthenia, Limb-Girdle, Familial, Formerly Lgm, Formerly Congenital Myasthenic Syndrome Type Ib, Formerly Cms1b, Formerly Cms Ib, Formerly Myasthenic Myopathy, Formerly Familial Limb-Girdle Myasthenia Cms1b Cms Ib Congenital Myasthenic Syndrome Type 1b Congenital Myasthenic Syndrome Type Ib Myasthenic Myopathy Myasthenic Syndrome, Congenital, Type 10 Congenital Myasthenic Syndrome Ib Myopathy In Myasthenia Gravis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03081	CPA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18234	Cpa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24713	Cpa2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CPA2	VGNC	VGNC:61112
Macaca mulatta	CPA2	VGNC	VGNC:108393
Rattus norvegicus	CPA2	RGD	RGD:1305563
Mus musculus	CPA2	MGD	MGI:3617840
Others	CPA2	NCBI