Edn2 - endothelin 2 Gene

Also Known as VIC; ET-2; PPET2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13615

Summary

This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a potent vasoconstrictive peptide. This gene is abundantly expressed in the gastrointestinal tract, strongly induced in photorecepteror cells in retinal diseases and injury, and produced by microglia and macrophages in the early stages of glaucoma. Mice lacking the encoded protein exhibit severe growth retardation, hypothermia and juvenile lethality. [provided by RefSeq, Feb 2016]

Edn2 Products (1)

mRNA Protein Name
NM_007902.3 NP_031928.2 endothelin-2 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
24043815 MGI
involved in angiogenesis IGI
IGI: Inferred from genetic interaction
24043815 MGI
involved in axon extension IDA
IDA: Inferred from direct assay
18401410 MGI
involved in cell tip growth IDA
IDA: Inferred from direct assay
24043815 MGI
involved in endothelial cell migration IDA
IDA: Inferred from direct assay
24043815 MGI
acts upstream of or within energy homeostasis IMP
IMP: Inferred from mutant phenotype
23676500 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
23676500 MGI
involved in neuron projection development IDA
IDA: Inferred from direct assay
24875861 MGI
involved in positive regulation of prostaglandin-endoperoxide synthase activity IMP
IMP: Inferred from mutant phenotype
9492062 MGI
acts upstream of or within positive regulation of smooth muscle contraction IDA
IDA: Inferred from direct assay
2768235 MGI
involved in prostaglandin biosynthetic process IDA
IDA: Inferred from direct assay
9492062 MGI
acts upstream of smooth muscle contraction IDA
IDA: Inferred from direct assay
2768235 MGI
acts upstream of or within temperature homeostasis IMP
IMP: Inferred from mutant phenotype
23676500 MGI
involved in vasculature development IDA
IDA: Inferred from direct assay
24043815 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelin-2

  • preproendothelin-2

  • vasoactive intestinal contractor peptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04164 EDN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22152 Edn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Edn2 NCBI NCBI:1907