Egr1 - early growth response 1 Gene

Also Known as egr; TIS8; Zenk; Egr-1; NGFIA; Zfp-6; ETR103; Krox-1; Krox24; NGF1-A; NGFI-A; Zif268; Krox-24; A530045N19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13653

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to gamma radiation; regulation of gene expression; and regulation of hormone biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]

Egr1 Products (1)

mRNA Protein Name
NM_007913.5 NP_031939.1 early growth response protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
18323529 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20018936 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
8336701 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12689920 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20018936 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15958557 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
8336701 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
31467272 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18281035 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
8769660 MGI
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
12165491 MGI
involved in cellular response to gamma radiation IMP
IMP: Inferred from mutant phenotype
19057511 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26471974 MGI
involved in circadian temperature homeostasis IMP
IMP: Inferred from mutant phenotype
29138967 MGI
involved in estrous cycle IMP
IMP: Inferred from mutant phenotype
8703054 MGI
involved in locomotor rhythm IMP
IMP: Inferred from mutant phenotype
29138967 MGI
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18281035 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16033766 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7720589 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17202132 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
26471974 MGI
involved in positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
11100120 MGI
involved in positive regulation of gene expression via chromosomal CpG island demethylation IGI
IGI: Inferred from genetic interaction
31467272 MGI
involved in positive regulation of hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
8703054 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
11100120 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20018936 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8336701 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12165491 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23277542 MGI
involved in regulation of progesterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
8703054 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18323529 MGI
involved in response to glucose IDA
IDA: Inferred from direct assay
12689920 MGI
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
11100120 MGI
involved in response to insulin IDA
IDA: Inferred from direct assay
12689920 MGI
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
11100120 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8668170 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

early growth response protein 1

  • Krox-24 nuclear protein

  • nerve growth factor-induced protein A

  • transcription factor Zif268

  • zinc finger protein Krox-24

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-157549A Brivoligide sodium 99.37% Phase 2
HY-157549 Brivoligide / Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163731 EGR-1-IN-1 Inhibitor 99.07% Unkown
HY-W286743 Nε-(Carboxymethyl)-L-lysine Activator 99.70% Unkown
HY-202699 SHOC2-RAS PPI-IN-1 Inhibitor 99.50% Unkown
HY-169118 EGR-1-IN-2 Inhibitor 99.61% Unkown
HY-121246 Fluorofenidone Inhibitor 99.78% Unkown
HY-116818 Crebinostat Inhibitor 98.83% Unkown
HY-170415 EGR-1-IN-3 Inhibitor 99.13% Unkown
HY-125980 LX-3 Inhibitor 98.08% Unkown
HY-RS04215 EGR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146411 microRNA-21-IN-1 98.03% Unkown
HY-RS16606 Egr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131721 14,15-EET-SI Activator / Unkown
HY-180419 SF-3-030 / Unkown
HY-121246S Fluorofenidone-d3 Inhibitor / Unkown
HY-RS23040 Egr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990661 SAIT-301 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Egr1 NCBI NCBI:1958