Elf3 - E74-like factor 3 Gene

Also Known as ESX; jen; ESE-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13710

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in mammary gland involution and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blastocyst development; extracellular matrix organization; and regulation of transcription, DNA-templated. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human ELF3 (E74 like ETS transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Elf3 Products (2)

mRNA	Protein	Name
NM_001163131.1	NP_001156603.1	ETS-related transcription factor Elf-3 isoform 1
NM_007921.3	NP_031947.1	ETS-related transcription factor Elf-3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11893733	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11893733	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11893733	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11893733	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	11984530	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11893733	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	11893733	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	11984530	MGI
acts upstream of or within blastocyst development	IMP IMP: Inferred from mutant phenotype	16630543	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	11984530	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	11984530	MGI
involved in mammary gland involution	IDA IDA: Inferred from direct assay	9806763	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11893733	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16630543	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11893733	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11893733	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11984530	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ETS-related transcription factor Elf-3	epithelial-restricted with serine box epithelium-restricted Ets protein ESX epithelium-specific Ets transcription factor 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04300	ELF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-158005	Anticancer agent 195	Inducer	/	Unkown
HY-180490	eIF3e-IN-1	Inhibitor	/	Unkown
HY-RS17547	Efnb3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18612	Elf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19817	Sptbn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25098	Elf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Elf3	NCBI	NCBI:1999