ELF3 - E74 like ETS transcription factor 3 Gene

Also Known as ERT; ESX; EPR-1; ESE-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1999

About ELF3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,010,587-202,017,183 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues, 28 paralogues and is associated with 62 phenotypes. Biased expression in colon (RPKM 88.6), stomach (RPKM 68.2) and 13 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in inflammatory response; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ELF3 Products (2)

mRNA Protein Name
NM_001114309.2 NP_001107781.1 ETS-related transcription factor Elf-3
NM_004433.5 NP_004424.3 ETS-related transcription factor Elf-3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9234700 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10391676 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in inflammatory response IEP
IEP: Inferred from expression pattern
14715662 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10773884 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9234700 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELF3 Protein Structure

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (49 - 131)

Ets

Ets: Ets-domain (273 - 356)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

ETS-related transcription factor Elf-3

  • E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)

ELF3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83039 ESE1 Antibody (YA2784) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Ampulla Of Vater Cancer

  • Ampulla Of Vater Carcinoma

  • Ampullary Carcinoma

  • Malignant Tumour Of Ampulla Of Vater

  • Carcinoma Of Ampulla Of Vater

  • Carcinoma Of The Ampulla Of Vater

  • Ampulloma
Bladder Urothelial Carcinoma

  • Bladder Transitional Cell Carcinoma

  • Transitional Cell Carcinoma Of Bladder

  • Transitional Cell Carcinoma Of The Bladder

  • Urinary Bladder Urothelial Carcinoma

  • Urothelial Bladder Carcinoma

  • Carcinoma Transitional Cell Bladder

  • Tcc - [Transitional Cell Carcinoma] Of Bladder
Sarcoma, Synovial

  • Synovial Sarcoma

  • Synovialosarcoma

  • Synovial Cell Sarcoma

  • Sarcoma Synovial
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Duodenum Cancer

  • Duodenal Cancer

  • Duodenal Neoplasms

  • Cancer Of Duodenum

  • Duodenal Neoplasm

  • Duodenal Carcinoma

  • Cancer, Duodenal

  • Malignant Neoplasm Of Duodenum
Ampulla Of Vater Adenocarcinoma

  • Adenocarcinoma Of Ampulla Of Vater

  • Ampullary Adenocarcinoma
Isolated Growth Hormone Deficiency, Type Ii

  • Ighd Ii

  • Isolated Growth Hormone Deficiency Type Ii

  • IGHD2

  • Growth Hormone Deficiency, Isolated, Type Ii

  • Congenital Ighd Type Ii

  • Congenital Isolated Gh Deficiency Type Ii

  • Congenital Isolated Growth Hormone Deficiency Type Ii

  • Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant

  • Growth Hormone Deficiency, Isolated, Autosomal Dominant

  • Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant

  • Autosomal Dominant Isolated Growth Hormone Deficiency

  • Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency

  • Isolated Growth Hormone Deficiency Type 2

  • Growth Hormone Deficiency, Isolated Autosomal Dominant

  • Growth Hormone Deficiency, Isolated, 2

  • Growth Hormone Deficiency Isolated Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04300 ELF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158005 Anticancer agent 195 Inducer / Unkown
HY-180490 eIF3e-IN-1 Inhibitor / Unkown
HY-RS17547 Efnb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18612 Elf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19817 Sptbn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25098 Elf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ELF3 VGNC VGNC:72207
Rattus norvegicus ELF3 RGD RGD:1310687
Bos taurus ELF3 VGNC VGNC:28428
Felis catus ELF3 VGNC VGNC:61807
Canis familiaris ELF3 VGNC VGNC:40300
Mus musculus ELF3 MGD MGI:1101781
Others ELF3 NCBI