Emp2 - epithelial membrane protein 2 Gene

Also Known as XMP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13731

Summary

Enables Integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryo implantation; and membrane raft assembly. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; medulla oblongata lateral wall; naris epithelium; respiratory system; and ventricular layer. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Emp2 Products (1)

mRNA Protein Name
NM_007929.2 NP_031955.2 epithelial membrane protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
12189152 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
12763482 MGI
NOT involved in caveola assembly IDA
IDA: Inferred from direct assay
14978215 MGI
involved in early endosome to late endosome transport IDA
IDA: Inferred from direct assay
18400107 MGI
involved in embryo implantation IMP
IMP: Inferred from mutant phenotype
16487956 MGI
involved in embryonic process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
28295343 MGI
involved in heart formation IMP
IMP: Inferred from mutant phenotype
30773261 MGI
involved in membrane raft assembly IDA
IDA: Inferred from direct assay
14978215 MGI
involved in natural killer cell proliferation IMP
IMP: Inferred from mutant phenotype
28295343 MGI
involved in neutrophil migration IMP
IMP: Inferred from mutant phenotype
31550239 MGI
involved in plasma membrane raft assembly IMP
IMP: Inferred from mutant phenotype
31550239 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
28295343 MGI
involved in positive regulation of cardiac epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
30773261 MGI
acts upstream of or within positive regulation of integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
16216233 MGI
involved in protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
31550239 MGI
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
12189152 MGI
involved in regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
12189152 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12189152 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
16487956 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16216233 MGI
NOT colocalizes with caveola IDA
IDA: Inferred from direct assay
14978215 MGI
located in cell surface IDA
IDA: Inferred from direct assay
16487956 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16216233 MGI
colocalizes with cytoplasmic vesicle IDA
IDA: Inferred from direct assay
12189152 MGI
colocalizes with membrane raft IDA
IDA: Inferred from direct assay
12763482 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
14978215 MGI
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
12189152 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epithelial membrane protein 2

  • EMP-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04360 EMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18355 Emp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24834 Emp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Emp2 NCBI NCBI:2013