Dmtn - dematin actin binding protein Gene

Also Known as Epb49; Epb4.9; dematin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13829

Summary

Enables protein self-association. Involved in several processes, including calcium-mediated signaling; negative regulation of protein phosphorylation; and regulation of cell-substrate adhesion. Located in several cellular components, including cortical cytoskeleton; perinuclear region of cytoplasm; and postsynaptic density. Is expressed in central nervous system; dorsal root ganglion; liver lobe; and sensory organ. Orthologous to human DMTN (dematin actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Dmtn Products (13)

mRNA Protein Name
NM_001252662.1 NP_001239591.1 dematin isoform 1
NM_001252663.1 NP_001239592.1 dematin isoform 2
NM_001252664.1 NP_001239593.1 dematin isoform 3
NM_001252665.1 NP_001239594.1 dematin isoform 4
NM_001252666.1 NP_001239595.1 dematin isoform 4
NM_001360024.1 NP_001346953.1 dematin isoform 1
NM_001360025.1 NP_001346954.1 dematin isoform 1
NM_001360026.1 NP_001346955.1 dematin isoform 1
NM_001360027.1 NP_001346956.1 dematin isoform 2
NM_001360028.1 NP_001346957.1 dematin isoform 3
NM_001360029.1 NP_001346958.1 dematin isoform 4
NM_001360030.1 NP_001346959.1 dematin isoform 3
NM_013514.4 NP_038542.1 dematin isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
12011427 MGI
involved in endoplasmic reticulum tubular network organization IMP
IMP: Inferred from mutant phenotype
23060452 MGI
involved in erythrocyte development IMP
IMP: Inferred from mutant phenotype
12011427 MGI
involved in negative regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in negative regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in negative regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in negative regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in negative regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in positive regulation of fibroblast migration IDA
IDA: Inferred from direct assay
18505823 MGI
involved in positive regulation of wound healing IMP
IMP: Inferred from mutant phenotype
18505823 MGI
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
12011427 MGI
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
18505823 MGI
involved in smooth endoplasmic reticulum calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
23060452 MGI
Cellular Component GO Annotation Evidence References Source
located in cell projection membrane IDA
IDA: Inferred from direct assay
18505823 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18505823 MGI
located in membrane IDA
IDA: Inferred from direct assay
18723693 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18505823 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
is active in synapse EXP
EXP: Inferred from Experiment
34269176 MGI
is active in synapse IDA
IDA: Inferred from direct assay
34269176 MGI
is active in synapse IMP
IMP: Inferred from mutant phenotype
34269176 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dematin

  • erythrocyte membrane protein band 4.9

  • erythrocyte protein band 4.9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03834 DMTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22141 Dmtn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28662 Dmtn Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dmtn NCBI NCBI:2039